6g9x
From Proteopedia
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(New page: '''Unreleased structure''' The entry 6g9x is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a MFS transporter at 2.54 Angstroem resolution== | |
| + | <StructureSection load='6g9x' size='340' side='right'caption='[[6g9x]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6g9x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Syntrophobacter_fumaroxidans_MPOB Syntrophobacter fumaroxidans MPOB]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G9X FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=JKE:2-SULFANYLBENZOIC+ACID'>JKE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g9x OCA], [https://pdbe.org/6g9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g9x RCSB], [https://www.ebi.ac.uk/pdbsum/6g9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g9x ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SFMCT_SYNFM SFMCT_SYNFM] Proton-coupled L-lactate specific transporter.<ref>PMID:31201333</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | In human and other mammalian cells, transport of L-lactate across plasma membranes is mainly catalyzed by monocarboxylate transporters (MCTs) of the SLC16 solute carrier family. MCTs play an important role in cancer metabolism and are promising targets for tumor treatment. Here, we report the crystal structures of an SLC16 family homologue with two different bound ligands at 2.54 and 2.69 A resolution. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structural information together with a detailed structure-based analysis of the transport function provide important insights into the molecular working mechanisms of ligand binding and L-lactate transport. | ||
| - | + | Mechanistic basis of L-lactate transport in the SLC16 solute carrier family.,Bosshart PD, Kalbermatter D, Bonetti S, Fotiadis D Nat Commun. 2019 Jun 14;10(1):2649. doi: 10.1038/s41467-019-10566-6. PMID:31201333<ref>PMID:31201333</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6g9x" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Syntrophobacter fumaroxidans MPOB]] | ||
| + | [[Category: Bonetti S]] | ||
| + | [[Category: Bosshart P]] | ||
| + | [[Category: Fotiadis D]] | ||
| + | [[Category: Kalbermatter D]] | ||
Current revision
Crystal structure of a MFS transporter at 2.54 Angstroem resolution
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