5vas

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:45, 4 October 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Pekin duck egg lysozyme isoform III (DEL-III), orthorhombic form==
==Pekin duck egg lysozyme isoform III (DEL-III), orthorhombic form==
-
<StructureSection load='5vas' size='340' side='right' caption='[[5vas]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
+
<StructureSection load='5vas' size='340' side='right'caption='[[5vas]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5vas]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anas_platyrhynchos Anas platyrhynchos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VAS FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5vas]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anas_platyrhynchos Anas platyrhynchos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VAS FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5v8g|5v8g]], [[5v92|5v92]], [[5v94|5v94]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vas OCA], [https://pdbe.org/5vas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vas RCSB], [https://www.ebi.ac.uk/pdbsum/5vas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vas ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vas OCA], [http://pdbe.org/5vas PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vas RCSB], [http://www.ebi.ac.uk/pdbsum/5vas PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vas ProSAT]</span></td></tr>
+
</table>
</table>
-
== Function ==
+
<div style="background-color:#fffaf0;">
-
[[http://www.uniprot.org/uniprot/U3J0P1_ANAPL U3J0P1_ANAPL]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.[SAAS:SAAS00858876]
+
== Publication Abstract from PubMed ==
 +
Duck egg lysozyme (DEL) is a widely used model antigen owing to its capacity to bind with differential affinity to anti-chicken egg lysozyme antibodies. However, no structures of DEL have so far been reported, and the situation had been complicated by the presence of multiple isoforms and conflicting reports of primary sequence. Here, the structures of two DEL isoforms from the eggs of the commonly used Pekin duck (Anas platyrhynchos) are reported. Using structural analyses in combination with mass spectrometry, non-ambiguous DEL primary sequences are reported. Furthermore, the structures and sequences determined here enable rationalization of the binding affinity of DEL for well documented landmark anti-lysozyme antibodies.
 +
 
 +
Structural basis of antigen recognition: crystal structure of duck egg lysozyme.,Langley DB, Crossett B, Schofield P, Jackson J, Zeraati M, Maltby D, Christie M, Burnett D, Brink R, Goodnow C, Christ D Acta Crystallogr D Struct Biol. 2017 Nov 1;73(Pt 11):910-920. doi:, 10.1107/S2059798317013730. Epub 2017 Oct 25. PMID:29095163<ref>PMID:29095163</ref>
 +
 
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 5vas" style="background-color:#fffaf0;"></div>
 +
 
 +
==See Also==
 +
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Anas platyrhynchos]]
[[Category: Anas platyrhynchos]]
-
[[Category: Lysozyme]]
+
[[Category: Large Structures]]
-
[[Category: Christ, D]]
+
[[Category: Christ D]]
-
[[Category: Christie, M]]
+
[[Category: Christie M]]
-
[[Category: Langley, D B]]
+
[[Category: Langley DB]]
-
[[Category: Duck lysozyme]]
+
-
[[Category: Glycosyl hydrolase]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: N-acetylmuramidase]]
+

Current revision

Pekin duck egg lysozyme isoform III (DEL-III), orthorhombic form

PDB ID 5vas

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5vas"
Personal tools