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6b2v

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==Pyran synthase domain from module nine of the sorangicin pathway==
==Pyran synthase domain from module nine of the sorangicin pathway==
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<StructureSection load='6b2v' size='340' side='right' caption='[[6b2v]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<StructureSection load='6b2v' size='340' side='right'caption='[[6b2v]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6b2v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B2V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6b2v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sorangium_cellulosum Sorangium cellulosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B2V FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b2v OCA], [http://pdbe.org/6b2v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b2v RCSB], [http://www.ebi.ac.uk/pdbsum/6b2v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b2v ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b2v OCA], [https://pdbe.org/6b2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b2v RCSB], [https://www.ebi.ac.uk/pdbsum/6b2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b2v ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/E5FNE5_SORCE E5FNE5_SORCE]
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trans-Acyltransferase assembly lines possess enzymatic domains often not observed in their better characterized cis-acyltransferase counterparts. Within this repertoire of largely unexplored biosynthetic machinery is a class of enzymes called the pyran synthases that catalyze the formation of five- and six-membered cyclic ethers from diverse polyketide chains. The 1.55 A resolution crystal structure of a pyran synthase domain excised from the ninth module of the sorangicin assembly line highlights the similarity of this enzyme to the ubiquitous dehydratase domain and provides insight into the mechanism of ring formation. Functional assays of point mutants reveal the central importance of the active site histidine that is shared with the dehydratases as well as the supporting role of a neighboring semiconserved asparagine.
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Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line.,Wagner DT, Zhang Z, Meoded RA, Cepeda AJ, Piel J, Keatinge-Clay AT ACS Chem Biol. 2018 Mar 1. doi: 10.1021/acschembio.8b00049. PMID:29481043<ref>PMID:29481043</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6b2v" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Keatinge-Clay, A T]]
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[[Category: Large Structures]]
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[[Category: Wagner, D T]]
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[[Category: Sorangium cellulosum]]
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[[Category: Antibiotic]]
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[[Category: Keatinge-Clay AT]]
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[[Category: Polyketide]]
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[[Category: Wagner DT]]
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[[Category: Pyran]]
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[[Category: Trans-at]]
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[[Category: Transferase]]
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Current revision

Pyran synthase domain from module nine of the sorangicin pathway

PDB ID 6b2v

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