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5lzv

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{{Large structure}}
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==Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1.==
==Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1.==
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<StructureSection load='5lzv' size='340' side='right' caption='[[5lzv]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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<SX load='5lzv' size='340' side='right' viewer='molstar' caption='[[5lzv]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lzv]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lzv]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LZV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ETF1, ERF1, RF1, SUP45L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzv OCA], [http://pdbe.org/5lzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzv RCSB], [http://www.ebi.ac.uk/pdbsum/5lzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzv OCA], [https://pdbe.org/5lzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lzv RCSB], [https://www.ebi.ac.uk/pdbsum/5lzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzv ProSAT]</span></td></tr>
</table>
</table>
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{{Large structure}}
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN]] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref> [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]
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[https://www.uniprot.org/uniprot/G1TT27_RABIT G1TT27_RABIT]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Receptor for activated protein kinase C 1|Receptor for activated protein kinase C 1]]
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*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: European rabbit]]
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Brown, A]]
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[[Category: Brown A]]
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[[Category: Hegde, R S]]
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[[Category: Hegde RS]]
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[[Category: Murray, J]]
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[[Category: Murray J]]
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[[Category: Ramakrishnan, V]]
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[[Category: Ramakrishnan V]]
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[[Category: Shao, S]]
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[[Category: Shao S]]
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[[Category: Taunton, J]]
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[[Category: Taunton J]]
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[[Category: Elongation]]
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[[Category: Ribosome]]
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[[Category: Translation]]
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Current revision

Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1.

5lzv, resolution 3.35Å

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