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| | ==Solution structure of the first LIM domain of thyroid receptor interacting protein 6 (TRIP6)== | | ==Solution structure of the first LIM domain of thyroid receptor interacting protein 6 (TRIP6)== |
| - | <StructureSection load='1x61' size='340' side='right' caption='[[1x61]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='1x61' size='340' side='right'caption='[[1x61]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1x61]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X61 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1x61]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X61 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRIP6, OIP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x61 OCA], [http://pdbe.org/1x61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x61 RCSB], [http://www.ebi.ac.uk/pdbsum/1x61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1x61 ProSAT], [http://www.topsan.org/Proteins/RSGI/1x61 TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x61 OCA], [https://pdbe.org/1x61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x61 RCSB], [https://www.ebi.ac.uk/pdbsum/1x61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x61 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x61 TOPSAN]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/TRIP6_HUMAN TRIP6_HUMAN]] Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.<ref>PMID:15489293</ref> <ref>PMID:14688263</ref> <ref>PMID:16624523</ref> <ref>PMID:19017743</ref> | + | [https://www.uniprot.org/uniprot/TRIP6_HUMAN TRIP6_HUMAN] Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.<ref>PMID:15489293</ref> <ref>PMID:14688263</ref> <ref>PMID:16624523</ref> <ref>PMID:19017743</ref> |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| - | [[Category: Hayashi, F]] | + | [[Category: Large Structures]] |
| - | [[Category: Nagashima, T]] | + | [[Category: Hayashi F]] |
| - | [[Category: Qin, X R]] | + | [[Category: Nagashima T]] |
| - | [[Category: Structural genomic]] | + | [[Category: Qin XR]] |
| - | [[Category: Yokoyama, S]] | + | [[Category: Yokoyama S]] |
| - | [[Category: Cell adhesion]]
| + | |
| - | [[Category: Lim domain]]
| + | |
| - | [[Category: National project on protein structural and functional analyse]]
| + | |
| - | [[Category: Nppsfa]]
| + | |
| - | [[Category: Opa-interacting protein 1]]
| + | |
| - | [[Category: Rsgi]]
| + | |
| Structural highlights
Function
TRIP6_HUMAN Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.[1] [2] [3] [4]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Kassel O, Schneider S, Heilbock C, Litfin M, Gottlicher M, Herrlich P. A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters. Genes Dev. 2004 Oct 15;18(20):2518-28. PMID:15489293 doi:http://dx.doi.org/10.1101/gad.322404
- ↑ Xu J, Lai YJ, Lin WC, Lin FT. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. J Biol Chem. 2004 Mar 12;279(11):10459-68. Epub 2003 Dec 18. PMID:14688263 doi:http://dx.doi.org/10.1074/jbc.M311891200
- ↑ Solaz-Fuster MC, Gimeno-Alcaniz JV, Casado M, Sanz P. TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase. Cell Signal. 2006 Oct;18(10):1702-12. Epub 2006 Mar 6. PMID:16624523 doi:http://dx.doi.org/10.1016/j.cellsig.2006.01.021
- ↑ Chastre E, Abdessamad M, Kruglov A, Bruyneel E, Bracke M, Di Gioia Y, Beckerle MC, van Roy F, Kotelevets L. TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness. FASEB J. 2009 Mar;23(3):916-28. doi: 10.1096/fj.08-106344. Epub 2008 Nov 18. PMID:19017743 doi:http://dx.doi.org/10.1096/fj.08-106344
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