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1xdd

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==X-ray structure of LFA-1 I-domain in complex with LFA703 at 2.2A resolution==
==X-ray structure of LFA-1 I-domain in complex with LFA703 at 2.2A resolution==
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<StructureSection load='1xdd' size='340' side='right' caption='[[1xdd]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='1xdd' size='340' side='right'caption='[[1xdd]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xdd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XDD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xdd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XDD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AAY:8-[2-((2S)-4-HYDROXY-1-{[5-(HYDROXYMETHYL)-6-METHOXY-2-NAPHTHYL]METHYL}-6-OXOPIPERIDIN-2-YL)ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL+2-METHYLBUTANOATE'>AAY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xdg|1xdg]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AAY:8-[2-((2S)-4-HYDROXY-1-{[5-(HYDROXYMETHYL)-6-METHOXY-2-NAPHTHYL]METHYL}-6-OXOPIPERIDIN-2-YL)ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL+2-METHYLBUTANOATE'>AAY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xdd OCA], [http://pdbe.org/1xdd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xdd RCSB], [http://www.ebi.ac.uk/pdbsum/1xdd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xdd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xdd OCA], [https://pdbe.org/1xdd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xdd RCSB], [https://www.ebi.ac.uk/pdbsum/1xdd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xdd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
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[https://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Integrin|Integrin]]
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*[[Integrin 3D structures|Integrin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Dawson, J]]
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[[Category: Large Structures]]
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[[Category: Kallen, J]]
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[[Category: Dawson J]]
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[[Category: Weitz-Schmidt, G]]
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[[Category: Kallen J]]
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[[Category: Welzenbach, K]]
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[[Category: Weitz-Schmidt G]]
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[[Category: I-domain]]
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[[Category: Welzenbach K]]
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[[Category: Immune system]]
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[[Category: Rossmann fold]]
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Current revision

X-ray structure of LFA-1 I-domain in complex with LFA703 at 2.2A resolution

PDB ID 1xdd

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