5ybd
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray structure of ETS domain of Ergp55 in complex with E74DNA== | |
| - | + | <StructureSection load='5ybd' size='340' side='right'caption='[[5ybd]], [[Resolution|resolution]] 2.77Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ybd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_adunca Drosophila adunca], [https://en.wikipedia.org/wiki/Drosophila_saltans Drosophila saltans] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YBD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.769Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ybd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ybd OCA], [https://pdbe.org/5ybd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ybd RCSB], [https://www.ebi.ac.uk/pdbsum/5ybd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ybd ProSAT]</span></td></tr> |
| - | [[Category: Gangwar | + | </table> |
| - | [[Category: Saxena | + | == Disease == |
| + | [https://www.uniprot.org/uniprot/ERG_HUMAN ERG_HUMAN] Defects in ERG are a cause of Ewing sarcoma (ES) [MIM:[https://omim.org/entry/612219 612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving ERG is found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1. Note=Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ERG_HUMAN ERG_HUMAN] Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Drosophila adunca]] | ||
| + | [[Category: Drosophila saltans]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gangwar SP]] | ||
| + | [[Category: Saxena AK]] | ||
Current revision
X-ray structure of ETS domain of Ergp55 in complex with E74DNA
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