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| - | [[Image:2hcm.gif|left|200px]] | |
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| - | {{Structure
| + | ==Crystal structure of mouse putative dual specificity phosphatase complexed with zinc tungstate, New York Structural Genomics Consortium== |
| - | |PDB= 2hcm |SIZE=350|CAPTION= <scene name='initialview01'>2hcm</scene>, resolution 2.00Å
| + | <StructureSection load='2hcm' size='340' side='right'caption='[[2hcm]], [[Resolution|resolution]] 2.00Å' scene=''> |
| - | |SITE= <scene name='pdbsite=AC1:Wo4+Binding+Site+For+Residue+A+366'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+367'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Residue+A+368'>AC3</scene>, <scene name='pdbsite=AC4:Na+Binding+Site+For+Residue+A+370'>AC4</scene> and <scene name='pdbsite=AC5:Gol+Binding+Site+For+Residue+A+369'>AC5</scene>
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
| + | <table><tr><td colspan='2'>[[2hcm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HCM FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | |GENE= 0710001B24Rik ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00127 DSPc]</span>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hcm OCA], [https://pdbe.org/2hcm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hcm RCSB], [https://www.ebi.ac.uk/pdbsum/2hcm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hcm ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2hcm TOPSAN]</span></td></tr> |
| - | |RELATEDENTRY=
| + | </table> |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hcm OCA], [http://www.ebi.ac.uk/pdbsum/2hcm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hcm RCSB]</span>
| + | == Function == |
| - | }}
| + | [https://www.uniprot.org/uniprot/DUS28_MOUSE DUS28_MOUSE] |
| | + | == Evolutionary Conservation == |
| | + | [[Image:Consurf_key_small.gif|200px|right]] |
| | + | Check<jmol> |
| | + | <jmolCheckbox> |
| | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/2hcm_consurf.spt"</scriptWhenChecked> |
| | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| | + | <text>to colour the structure by Evolutionary Conservation</text> |
| | + | </jmolCheckbox> |
| | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hcm ConSurf]. |
| | + | <div style="clear:both"></div> |
| | | | |
| - | '''Crystal structure of mouse putative dual specificity phosphatase complexed with zinc tungstate, New York Structural Genomics Consortium'''
| + | ==See Also== |
| - | | + | *[[MAP kinase phosphatase|MAP kinase phosphatase]] |
| - | | + | __TOC__ |
| - | ==Overview== | + | </StructureSection> |
| - | The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
| + | [[Category: Large Structures]] |
| - | | + | |
| - | ==About this Structure==
| + | |
| - | 2HCM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCM OCA].
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| - | | + | |
| - | ==Reference==
| + | |
| - | Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]
| + | |
| | [[Category: Mus musculus]] | | [[Category: Mus musculus]] |
| - | [[Category: Single protein]]
| + | [[Category: Almo SC]] |
| - | [[Category: Almo, S C.]] | + | [[Category: Burley SK]] |
| - | [[Category: Burley, S K.]] | + | [[Category: Patskovsky Y]] |
| - | [[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
| + | |
| - | [[Category: Patskovsky, Y.]] | + | |
| - | [[Category: hydrolase]]
| + | |
| - | [[Category: new york structural genomix research consortium]]
| + | |
| - | [[Category: nysgxrc]]
| + | |
| - | [[Category: phosphatase]]
| + | |
| - | [[Category: protein structure initiative]]
| + | |
| - | [[Category: psi]]
| + | |
| - | [[Category: structural genomic]]
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| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:28:31 2008''
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