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6gbg
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6gbg is ON HOLD until Paper Publication Authors: Moonens, K., Kruse, T., Gerhard, M., Remaut, H. Description: Helicobacter pylori adhesin HopQ type...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Helicobacter pylori adhesin HopQ type I bound to the N-terminal domain of human CEACAM1== | |
| + | <StructureSection load='6gbg' size='340' side='right' caption='[[6gbg]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6gbg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helpg Helpg] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GBG FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CEACAM1, BGP, BGP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), hopQ, HPG27_1120 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=563041 HELPG])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gbg OCA], [http://pdbe.org/6gbg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gbg RCSB], [http://www.ebi.ac.uk/pdbsum/6gbg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gbg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The human gastric pathogen Helicobacter pylori is a major causative agent of gastritis, peptic ulcer disease, and gastric cancer. As part of its adhesive lifestyle, the bacterium targets members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family by the conserved outer membrane adhesin HopQ. The HopQ-CEACAM1 interaction is associated with inflammatory responses and enables the intracellular delivery and phosphorylation of the CagA oncoprotein via a yet unknown mechanism. Here, we generated crystal structures of HopQ isotypes I and II bound to the N-terminal domain of human CEACAM1 (C1ND) and elucidated the structural basis of H. pylori specificity toward human CEACAM receptors. Both HopQ alleles target the beta-strands G, F, and C of C1ND, which form the trans dimerization interface in homo- and heterophilic CEACAM interactions. Using SAXS, we show that the HopQ ectodomain is sufficient to induce C1ND monomerization and thus providing H. pylori a route to influence CEACAM-mediated cell adherence and signaling events. | ||
| - | + | Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs.,Moonens K, Hamway Y, Neddermann M, Reschke M, Tegtmeyer N, Kruse T, Kammerer R, Mejias-Luque R, Singer BB, Backert S, Gerhard M, Remaut H EMBO J. 2018 Jun 1. pii: embj.201798665. doi: 10.15252/embj.201798665. PMID:29858229<ref>PMID:29858229</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 6gbg" style="background-color:#fffaf0;"></div> | |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Helpg]] | ||
| + | [[Category: Human]] | ||
[[Category: Gerhard, M]] | [[Category: Gerhard, M]] | ||
| + | [[Category: Kruse, T]] | ||
| + | [[Category: Moonens, K]] | ||
| + | [[Category: Remaut, H]] | ||
| + | [[Category: Adhesin]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Helicobacter outer membrane protein]] | ||
| + | [[Category: Helicobacter pylori]] | ||
Current revision
Helicobacter pylori adhesin HopQ type I bound to the N-terminal domain of human CEACAM1
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