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5wc2

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==Crystal Structure of ADP-bound human TRIP13==
==Crystal Structure of ADP-bound human TRIP13==
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<StructureSection load='5wc2' size='340' side='right' caption='[[5wc2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='5wc2' size='340' side='right'caption='[[5wc2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wc2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WC2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wc2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WC2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wc2 OCA], [http://pdbe.org/5wc2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wc2 RCSB], [http://www.ebi.ac.uk/pdbsum/5wc2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wc2 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wc2 OCA], [https://pdbe.org/5wc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wc2 RCSB], [https://www.ebi.ac.uk/pdbsum/5wc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wc2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PCH2_HUMAN PCH2_HUMAN]] Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).
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[https://www.uniprot.org/uniprot/PCH2_HUMAN PCH2_HUMAN] Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Jeong, B C]]
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[[Category: Homo sapiens]]
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[[Category: Luo, X]]
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[[Category: Large Structures]]
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[[Category: Atpase]]
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[[Category: Jeong B-C]]
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[[Category: Cell cycle]]
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[[Category: Luo X]]
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[[Category: Mad2]]
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[[Category: P31comet]]
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[[Category: Spindle assembly checkpoint]]
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[[Category: Trip13]]
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Current revision

Crystal Structure of ADP-bound human TRIP13

PDB ID 5wc2

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