5xj4

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==Complex structure of durvalumab-scFv/PD-L1==
==Complex structure of durvalumab-scFv/PD-L1==
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<StructureSection load='5xj4' size='340' side='right' caption='[[5xj4]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='5xj4' size='340' side='right'caption='[[5xj4]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5xj4]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XJ4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5xj4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XJ4 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5xj3|5xj3]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xj4 OCA], [http://pdbe.org/5xj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xj4 RCSB], [http://www.ebi.ac.uk/pdbsum/5xj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xj4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xj4 OCA], [https://pdbe.org/5xj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xj4 RCSB], [https://www.ebi.ac.uk/pdbsum/5xj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xj4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
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[https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chai, Y]]
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[[Category: Homo sapiens]]
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[[Category: Gao, G F]]
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[[Category: Large Structures]]
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[[Category: Liu, K]]
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[[Category: Chai Y]]
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[[Category: Qi, J]]
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[[Category: Gao GF]]
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[[Category: Tan, S]]
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[[Category: Liu K]]
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[[Category: Complex structure]]
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[[Category: Qi J]]
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[[Category: Durvalumab]]
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[[Category: Tan S]]
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[[Category: Immune system]]
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[[Category: Pd-l1]]
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Current revision

Complex structure of durvalumab-scFv/PD-L1

PDB ID 5xj4

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