4cyi

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{{Large structure}}
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==Chaetomium thermophilum Pan3==
==Chaetomium thermophilum Pan3==
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<StructureSection load='4cyi' size='340' side='right' caption='[[4cyi]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
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<StructureSection load='4cyi' size='340' side='right'caption='[[4cyi]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cyi]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_144.50 Cbs 144.50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CYI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cyi]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CYI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyi OCA], [https://pdbe.org/4cyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cyi RCSB], [https://www.ebi.ac.uk/pdbsum/4cyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cyi ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cyj|4cyj]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyi OCA], [http://pdbe.org/4cyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cyi RCSB], [http://www.ebi.ac.uk/pdbsum/4cyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cyi ProSAT]</span></td></tr>
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</table>
</table>
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{{Large structure}}
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== Function ==
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[[https://www.uniprot.org/uniprot/PAN3_CHATD PAN3_CHATD]] Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.[HAMAP-Rule:MF_03181]<ref>PMID:24872509</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cbs 144 50]]
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[[Category: Chaetomium thermophilum]]
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[[Category: Allen, M D]]
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[[Category: Large Structures]]
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[[Category: Bycroft, M]]
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[[Category: Allen MD]]
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[[Category: Gordiyenko, Y]]
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[[Category: Bycroft M]]
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[[Category: McLaughlin, S H]]
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[[Category: Gordiyenko Y]]
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[[Category: Meineke, B]]
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[[Category: McLaughlin SH]]
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[[Category: Olsen, T M]]
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[[Category: Meineke B]]
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[[Category: Passmore, L A]]
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[[Category: Olsen TM]]
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[[Category: Robinson, C V]]
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[[Category: Passmore LA]]
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[[Category: Stewart, M]]
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[[Category: Robinson CV]]
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[[Category: Valkov, E]]
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[[Category: Stewart M]]
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[[Category: Wolf, J]]
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[[Category: Valkov E]]
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[[Category: Transferase]]
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[[Category: Wolf J]]

Current revision

Chaetomium thermophilum Pan3

PDB ID 4cyi

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