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6ayn

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Current revision (14:28, 4 October 2023) (edit) (undo)
 
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==Structure of cetuximab with aminoheptanoic acid-linked N-(3-aminopropyl)-L-arginine meditope variant==
==Structure of cetuximab with aminoheptanoic acid-linked N-(3-aminopropyl)-L-arginine meditope variant==
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<StructureSection load='6ayn' size='340' side='right' caption='[[6ayn]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
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<StructureSection load='6ayn' size='340' side='right'caption='[[6ayn]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ayn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AYN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ayn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AYN FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=011:7-AMINOHEPTANOIC+ACID'>011</scene>, <scene name='pdbligand=C4G:'>C4G</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5id0|5id0]], [[6au5|6au5]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=011:7-AMINOHEPTANOIC+ACID'>011</scene>, <scene name='pdbligand=C4G:N~5~-[N-(3-aminopropyl)carbamimidoyl]-L-ornithine'>C4G</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IGKC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ayn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ayn OCA], [https://pdbe.org/6ayn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ayn RCSB], [https://www.ebi.ac.uk/pdbsum/6ayn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ayn ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ayn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ayn OCA], [http://pdbe.org/6ayn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ayn RCSB], [http://www.ebi.ac.uk/pdbsum/6ayn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ayn ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IGKC_HUMAN IGKC_HUMAN] Defects in IGKC are the cause of immunoglobulin kappa light chain deficiency (IGKCD) [MIM:[https://omim.org/entry/614102 614102]. IGKCD is a disease characterized by the complete absence of immunoglobulin kappa chains.<ref>PMID:3931219</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/IGKC_HUMAN IGKC_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Homo sapiens]]
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[[Category: Bzymek, K P]]
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[[Category: Large Structures]]
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[[Category: Williams, J C]]
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[[Category: Mus musculus]]
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[[Category: Anti-egfr]]
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[[Category: Synthetic construct]]
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[[Category: Antibody]]
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[[Category: Bzymek KP]]
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[[Category: Immune system]]
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[[Category: Williams JC]]

Current revision

Structure of cetuximab with aminoheptanoic acid-linked N-(3-aminopropyl)-L-arginine meditope variant

PDB ID 6ayn

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