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1z2w

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==Crystal structure of mouse Vps29 complexed with Mn2+==
==Crystal structure of mouse Vps29 complexed with Mn2+==
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<StructureSection load='1z2w' size='340' side='right' caption='[[1z2w]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='1z2w' size='340' side='right'caption='[[1z2w]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1z2w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z2W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1z2w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z2W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s3m|1s3m]], [[1s3n|1s3n]], [[1z2x|1z2x]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Vps29 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z2w OCA], [https://pdbe.org/1z2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z2w RCSB], [https://www.ebi.ac.uk/pdbsum/1z2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z2w ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z2w OCA], [http://pdbe.org/1z2w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z2w RCSB], [http://www.ebi.ac.uk/pdbsum/1z2w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z2w ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VPS29_MOUSE VPS29_MOUSE]] Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro).
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[https://www.uniprot.org/uniprot/VPS29_MOUSE VPS29_MOUSE] Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Collins, B M]]
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[[Category: Mus musculus]]
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[[Category: Owen, D J]]
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[[Category: Collins BM]]
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[[Category: Seaman, M N.J]]
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[[Category: Owen DJ]]
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[[Category: Skinner, C F]]
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[[Category: Seaman MNJ]]
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[[Category: Watson, P J]]
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[[Category: Skinner CF]]
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[[Category: Manganese]]
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[[Category: Watson PJ]]
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[[Category: Phosphatase]]
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[[Category: Protein transport]]
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[[Category: Retromer]]
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[[Category: Vps29]]
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Current revision

Crystal structure of mouse Vps29 complexed with Mn2+

PDB ID 1z2w

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