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Disintegrin

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== Relevance ==
== Relevance ==
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Disintegrins which have anti-integrin activity, have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer. Disintegrin also functions in inhibition of adipogenesis<ref>PMID:18508683</ref>.
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Disintegrins, which have anti-integrin activity, have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer. Disintegrin also functions in inhibition of adipogenesis<ref>PMID:18508683</ref>.
</StructureSection>
</StructureSection>
== 3D Structures of Disintegrin ==
== 3D Structures of Disintegrin ==
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[[1j2l]] – trimestatin - ''Trimeresurus flavovidrius''<br />
[[1j2l]] – trimestatin - ''Trimeresurus flavovidrius''<br />
[[2pjf]], [[1q7i]], [[1q7j]], [[1n4y]] – Cr rhodostoxin residues 1-68 – ''Calloselasma rhodostoma'' – NMR<br />
[[2pjf]], [[1q7i]], [[1q7j]], [[1n4y]] – Cr rhodostoxin residues 1-68 – ''Calloselasma rhodostoma'' – NMR<br />
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[[2pjg]], [[2pji]], [[2ljv]] - Cr rhodostoxin (mutant) – NMR<br />
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[[2pjg]], [[2pji]], [[2ljv]] - Cr rhodostoxin (mutant) 1-68 – NMR<br />
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[[3uci]] - Cr rhodostoxin (mutant)<br />
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[[3uci]], [[4m4c]], [[4r5r]], [[4r5u]], [[4rqg]] - Cr rhodostoxin (mutant) 408-475<br />
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[[4rqg]] – Cr rhodostomin <br />
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[[2m75]], [[2m7f]], [[2m7h]] - Cr rhodostoxin (mutant) 408-475 – NMR<br />
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[[4r5r]], [[4r5u]] – Cr rhodostomin (mutant)<br />
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[[1z1x]], [[1tej]] – Ec disintegrin – ''Echis carinatus''<br />
[[1z1x]], [[1tej]] – Ec disintegrin – ''Echis carinatus''<br />
[[1rmr]] – Ec schistatin<br />
[[1rmr]] – Ec schistatin<br />
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[[6lsq]] – Ec echistatin<br />
[[1ro3]], [[2ech]] – Ec echistatin - NMR<br />
[[1ro3]], [[2ech]] – Ec echistatin - NMR<br />
[[1l3x]] – salmosin – ''Gloydius brevicaudus'' – NMR<br />
[[1l3x]] – salmosin – ''Gloydius brevicaudus'' – NMR<br />

Current revision

Disintegrin, 1z1x

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3D Structures of Disintegrin

Updated on 30-January-2023

2w9o, 2w9u, 2w9v, 2w9w – jerdostatin residues 68-110 – Trimeresurus jerdonii – NMR
1j2l – trimestatin - Trimeresurus flavovidrius
2pjf, 1q7i, 1q7j, 1n4y – Cr rhodostoxin residues 1-68 – Calloselasma rhodostoma – NMR
2pjg, 2pji, 2ljv - Cr rhodostoxin (mutant) 1-68 – NMR
3uci, 4m4c, 4r5r, 4r5u, 4rqg - Cr rhodostoxin (mutant) 408-475
2m75, 2m7f, 2m7h - Cr rhodostoxin (mutant) 408-475 – NMR
1z1x, 1tej – Ec disintegrin – Echis carinatus
1rmr – Ec schistatin
6lsq – Ec echistatin
1ro3, 2ech – Ec echistatin - NMR
1l3x – salmosin – Gloydius brevicaudus – NMR
1mpz – obtustatin – Macrovipera obtusa - NMR
3c05 – acostatin-α residues 48-109+acostatin-β residues 419-482 – copperhead
3dsl – bothropasin - Jararaca
2dw0, 2dw1, 2dw2 – catrocollastatin – rattlesnake
2mop, 2mp5 – bitistatin – African puff adder - NMR


References

  1. ↑ McLane MA, Sanchez EE, Wong A, Paquette-Straub C, Perez JC. Disintegrins. Curr Drug Targets Cardiovasc Haematol Disord. 2004 Dec;4(4):327-55. PMID:15578957
  2. ↑ McLane MA, Joerger T, Mahmoud A. Disintegrins in health and disease. Front Biosci. 2008 May 1;13:6617-37. PMID:18508683

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