2hn1

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[[Image:2hn1.gif|left|200px]]
 
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{{Structure
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==Crystal structure of a CorA soluble domain from A. fulgidus in complex with Co2+==
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|PDB= 2hn1 |SIZE=350|CAPTION= <scene name='initialview01'>2hn1</scene>, resolution 2.900&Aring;
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<StructureSection load='2hn1' size='340' side='right'caption='[[2hn1]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>
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<table><tr><td colspan='2'>[[2hn1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HN1 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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|GENE= CorA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 Archaeoglobus fulgidus])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hn1 OCA], [https://pdbe.org/2hn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hn1 RCSB], [https://www.ebi.ac.uk/pdbsum/2hn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hn1 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2hn2|2HN2]], [[2bbj|2BBJ]], [[2bbh|2BBH]], [[2iub|2IUB]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hn1 OCA], [http://www.ebi.ac.uk/pdbsum/2hn1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hn1 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/O29472_ARCFU O29472_ARCFU] Mediates influx of magnesium ions.[RuleBase:RU362010]
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== Evolutionary Conservation ==
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'''Crystal structure of a CorA soluble domain from A. fulgidus in complex with Co2+'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hn/2hn1_consurf.spt"</scriptWhenChecked>
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We describe the CorA Mg(2+) transporter homologue from Thermotoga maritima in complex with 12 divalent cations at 3.7 A resolution. One metal is found near the universally conserved GMN motif, apparently stabilized within the transmembrane region. This portion of the selectivity filter might discriminate between the size and preferred coordination geometry of hydrated substrates. CorA may further achieve specificity by requiring the sequential dehydration of substrates along the length of its approximately 55 A long pore. Ten metal sites identified within the cytoplasmic funnel domain are linked to long extensions of the pore helices and regulate the transport status of CorA. We have characterized this region as an intrinsic divalent cation sensor and provide evidence that it functions as a Mg(2+)-specific homeostatic molecular switch. A proteolytic protection assay, biophysical data, and comparison to a soluble domain structure from Archaeoglobus fulgidus have revealed the potential reaction coordinate for this diverse family of transport proteins.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2HN1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HN1 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hn1 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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A structural basis for Mg2+ homeostasis and the CorA translocation cycle., Payandeh J, Pai EF, EMBO J. 2006 Aug 23;25(16):3762-73. Epub 2006 Aug 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16902408 16902408]
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</StructureSection>
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Pai, E F.]]
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[[Category: Pai EF]]
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[[Category: Payandeh, J.]]
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[[Category: Payandeh J]]
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[[Category: divalent cation]]
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[[Category: integral membrane protein fragment]]
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[[Category: metal transporter protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:32:35 2008''
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Current revision

Crystal structure of a CorA soluble domain from A. fulgidus in complex with Co2+

PDB ID 2hn1

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