6g73
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The dynamic nature of the VDAC1 channels in bilayers: human VDAC1 at 3.3 Angstrom resolution== |
| - | + | <StructureSection load='6g73' size='340' side='right'caption='[[6g73]], [[Resolution|resolution]] 3.27Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6g73]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G73 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene></td></tr> | |
| - | [[Category: | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VDAC1, VDAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g73 OCA], [http://pdbe.org/6g73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g73 RCSB], [http://www.ebi.ac.uk/pdbsum/6g73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g73 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VDAC1_HUMAN VDAC1_HUMAN]] Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.<ref>PMID:11845315</ref> <ref>PMID:15033708</ref> <ref>PMID:18755977</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Gribbon, P]] | [[Category: Gribbon, P]] | ||
| + | [[Category: Loew, C]] | ||
[[Category: Razeto, A]] | [[Category: Razeto, A]] | ||
| - | [[Category: | + | [[Category: Apoptosis]] |
| + | [[Category: B-barrel]] | ||
| + | [[Category: Cytochrome c release]] | ||
| + | [[Category: Ion-channel]] | ||
| + | [[Category: Outer mitochondrial membrane]] | ||
| + | [[Category: Transport protein]] | ||
Current revision
The dynamic nature of the VDAC1 channels in bilayers: human VDAC1 at 3.3 Angstrom resolution
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