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5y05

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==Structural characterization of msmeg_4306 from Mycobacterium smegmatis==
==Structural characterization of msmeg_4306 from Mycobacterium smegmatis==
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<StructureSection load='5y05' size='340' side='right' caption='[[5y05]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='5y05' size='340' side='right'caption='[[5y05]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5y05]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y05 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5y05]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y05 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.799&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y05 OCA], [http://pdbe.org/5y05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y05 RCSB], [http://www.ebi.ac.uk/pdbsum/5y05 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y05 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y05 OCA], [https://pdbe.org/5y05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y05 RCSB], [https://www.ebi.ac.uk/pdbsum/5y05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y05 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0R095_MYCS2 A0R095_MYCS2]
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The MSMEG_4306 gene from Mycobacterium smegmatis encodes a protein of unknown function with 242 amino-acid residues that contains a conserved zinc-ribbon domain at its C-terminus. Here, the crystal structure of MSMEG_4306 determined by the single-wavelength anomalous dispersion method using just one zinc ion co-purified with the protein is reported. The crystal structure of MSMEG_4306 shows a coiled-coil helix domain in the N-terminal region and a zinc-ribbon domain in the C-terminal region. A structural similarity search against the Protein Data Bank using MSMEG_4306 as a query revealed two similar structures, namely CT398 from Chlamydia trachomatis and HP0958 from Helicobacter pylori, although they share only approximately 15% sequence identity with MSMEG_4306. Based on comparative analysis, it is predicted that MSMEG_4306 may be involved in secretion systems, possibly by interacting with multiple proteins or nucleic acids.
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Crystal structure of the MSMEG_4306 gene product from Mycobacterium smegmatis.,Kumar A, Karthikeyan S Acta Crystallogr F Struct Biol Commun. 2018 Mar 1;74(Pt 3):166-173. doi:, 10.1107/S2053230X18002236. Epub 2018 Feb 26. PMID:29497021<ref>PMID:29497021</ref>
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==See Also==
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5y05" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Karthikeyan, S]]
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[[Category: Large Structures]]
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[[Category: Kumar, A]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Coiled coil helix]]
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[[Category: Karthikeyan S]]
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[[Category: Hypothetical]]
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[[Category: Kumar A]]
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[[Category: Unknown function]]
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[[Category: Zinc ribbon]]
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[[Category: Zinc-sad]]
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Current revision

Structural characterization of msmeg_4306 from Mycobacterium smegmatis

PDB ID 5y05

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