6ein

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==Crystal structure of KDM5B in complex with S49365a.==
==Crystal structure of KDM5B in complex with S49365a.==
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<StructureSection load='6ein' size='340' side='right' caption='[[6ein]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
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<StructureSection load='6ein' size='340' side='right'caption='[[6ein]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ein]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EIN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ein]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EIN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B7Z:8-[4-[2-[4-(3-oxidanylpropanoyl)piperazin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one'>B7Z</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ein FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ein OCA], [http://pdbe.org/6ein PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ein RCSB], [http://www.ebi.ac.uk/pdbsum/6ein PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ein ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B7Z:8-[4-[2-(4-propanoylpiperazin-1-yl)ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one'>B7Z</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ein FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ein OCA], [https://pdbe.org/6ein PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ein RCSB], [https://www.ebi.ac.uk/pdbsum/6ein PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ein ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
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[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
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==See Also==
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*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]
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*[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Homo sapiens]]
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[[Category: Bountra, C]]
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[[Category: Large Structures]]
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[[Category: Burgess-Brown, N A]]
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[[Category: Arrowsmith CH]]
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[[Category: Delft, F von]]
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[[Category: Bountra C]]
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[[Category: Edwards, A]]
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[[Category: Burgess-Brown NA]]
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[[Category: Huber, K]]
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[[Category: Edwards A]]
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[[Category: Kupinska, K]]
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[[Category: Huber K]]
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[[Category: Newman, J A]]
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[[Category: Kupinska K]]
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[[Category: Oppermann, U]]
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[[Category: Newman JA]]
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[[Category: Ruda, G F]]
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[[Category: Oppermann U]]
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[[Category: Srikannathasan, V]]
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[[Category: Ruda GF]]
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[[Category: Strain-Damerell, C]]
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[[Category: Srikannathasan V]]
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[[Category: Szykowska, A]]
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[[Category: Strain-Damerell C]]
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[[Category: Vazquez-Rodriguez, S A]]
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[[Category: Szykowska A]]
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[[Category: Wright, M]]
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[[Category: Vazquez-Rodriguez SA]]
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[[Category: Kdm5b lysine specific demethylase]]
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[[Category: Wright M]]
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[[Category: Oxidoreductase]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of KDM5B in complex with S49365a.

PDB ID 6ein

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