4auw

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==CRYSTAL STRUCTURE OF THE BZIP HOMODIMERIC MAFB IN COMPLEX WITH THE C- MARE BINDING SITE==
==CRYSTAL STRUCTURE OF THE BZIP HOMODIMERIC MAFB IN COMPLEX WITH THE C- MARE BINDING SITE==
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<StructureSection load='4auw' size='340' side='right' caption='[[4auw]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='4auw' size='340' side='right'caption='[[4auw]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4auw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4auw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AUW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTU:(2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTU</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4auw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4auw OCA], [http://pdbe.org/4auw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4auw RCSB], [http://www.ebi.ac.uk/pdbsum/4auw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4auw ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTU:(2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTU</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4auw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4auw OCA], [https://pdbe.org/4auw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4auw RCSB], [https://www.ebi.ac.uk/pdbsum/4auw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4auw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MAFB_MOUSE MAFB_MOUSE]] Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:10790365</ref> <ref>PMID:16443760</ref> <ref>PMID:16847325</ref> <ref>PMID:17901057</ref> <ref>PMID:17548468</ref> <ref>PMID:18199433</ref> <ref>PMID:19143053</ref>
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[https://www.uniprot.org/uniprot/MAFB_MOUSE MAFB_MOUSE] Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:10790365</ref> <ref>PMID:16443760</ref> <ref>PMID:16847325</ref> <ref>PMID:17901057</ref> <ref>PMID:17548468</ref> <ref>PMID:18199433</ref> <ref>PMID:19143053</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Holton, S]]
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[[Category: Mus musculus]]
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[[Category: Textor, L C]]
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[[Category: Synthetic construct]]
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[[Category: Wilmanns, M]]
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[[Category: Holton S]]
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[[Category: Dna]]
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[[Category: Textor LC]]
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[[Category: Macrophage]]
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[[Category: Wilmanns M]]
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[[Category: Transcription]]
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Current revision

CRYSTAL STRUCTURE OF THE BZIP HOMODIMERIC MAFB IN COMPLEX WITH THE C- MARE BINDING SITE

PDB ID 4auw

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