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2hph

From Proteopedia

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[[Image:2hph.jpg|left|200px]]
 
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{{Structure
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==High resolution structure of E. coli glucose/galactose binding protein bound with glucose==
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|PDB= 2hph |SIZE=350|CAPTION= <scene name='initialview01'>2hph</scene>, resolution 1.330&Aring;
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<StructureSection load='2hph' size='340' side='right'caption='[[2hph]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>
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<table><tr><td colspan='2'>[[2hph]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HPH FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.33&#8491;</td></tr>
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|GENE= mglB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hph OCA], [https://pdbe.org/2hph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hph RCSB], [https://www.ebi.ac.uk/pdbsum/2hph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hph ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1glg|1GLG]], [[2gbp|2GBP]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hph OCA], [http://www.ebi.ac.uk/pdbsum/2hph PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hph RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/MGLB_ECOLI MGLB_ECOLI] Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import (Probable). In addition, binds D-galactose and D-glucose and plays a role in the chemotaxis towards these two sugars by interacting with the Trg chemoreceptor (PubMed:3057628, PubMed:4927373). Chemotaxis requires MglB, but not MglA or MglC (PubMed:6294056).<ref>PMID:3057628</ref> <ref>PMID:4927373</ref> <ref>PMID:6294056</ref> <ref>PMID:1719366</ref> <ref>PMID:6294056</ref>
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== Evolutionary Conservation ==
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'''High resolution structure of E. coli glucose/galactose binding protein bound with glucose'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/2hph_consurf.spt"</scriptWhenChecked>
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2HPH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HPH OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hph ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cuneo, M J.]]
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[[Category: Cuneo MJ]]
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[[Category: Hellinga, H W.]]
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[[Category: Hellinga HW]]
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[[Category: chemotaxis]]
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[[Category: gbp]]
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[[Category: glucose binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:33:35 2008''
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Current revision

High resolution structure of E. coli glucose/galactose binding protein bound with glucose

PDB ID 2hph

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