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2hpv

From Proteopedia

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[[Image:2hpv.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of FMN-Dependent azoreductase from Enterococcus faecalis==
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|PDB= 2hpv |SIZE=350|CAPTION= <scene name='initialview01'>2hpv</scene>, resolution 2.00&Aring;
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<StructureSection load='2hpv' size='340' side='right'caption='[[2hpv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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<table><tr><td colspan='2'>[[2hpv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HPV FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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|GENE= azoR, azoA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1182 AcpD]</span>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">azoR, azoA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>
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|RELATEDENTRY=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hpv OCA], [https://pdbe.org/2hpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hpv RCSB], [https://www.ebi.ac.uk/pdbsum/2hpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hpv ProSAT], [https://www.topsan.org/Proteins/SECSG/2hpv TOPSAN]</span></td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hpv OCA], [http://www.ebi.ac.uk/pdbsum/2hpv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hpv RCSB]</span>
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</table>
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}}
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== Function ==
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[[https://www.uniprot.org/uniprot/AZOR_ENTFA AZOR_ENTFA]] Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can also reduce a wide range of sulfonated azo dyes. The substrate preference order is methyl Red > Orange II > Ponceau BS > Ponceau S > Orange G > Amaranth.[HAMAP-Rule:MF_01216]
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'''Crystal structure of FMN-Dependent azoreductase from Enterococcus faecalis'''
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==About this Structure==
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<jmolCheckbox>
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2HPV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HPV OCA].
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/2hpv_consurf.spt"</scriptWhenChecked>
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[[Category: Enterococcus faecalis]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Single protein]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Chen, H.]]
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</jmolCheckbox>
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[[Category: Chen, L.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hpv ConSurf].
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[[Category: Liu, Z J.]]
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<div style="clear:both"></div>
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[[Category: Rose, J.]]
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__TOC__
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[[Category: SECSG, Southeast Collaboratory for Structural Genomics.]]
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</StructureSection>
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[[Category: Wang, B C.]]
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[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]
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[[Category: azoreductase]]
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[[Category: Large Structures]]
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[[Category: enterococcus faecali]]
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[[Category: Chen, H]]
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[[Category: protein structure initiative]]
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[[Category: Chen, L]]
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[[Category: psi]]
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[[Category: Liu, Z J]]
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[[Category: secsg]]
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[[Category: Rose, J]]
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[[Category: southeast collaboratory for structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural genomic]]
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[[Category: Wang, B C]]
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[[Category: Azoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:33:45 2008''
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[[Category: Enterococcus faecali]]
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[[Category: Oxidoreductase]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Secsg]]

Current revision

Crystal structure of FMN-Dependent azoreductase from Enterococcus faecalis

PDB ID 2hpv

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