2hqv

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[[Image:2hqv.gif|left|200px]]
 
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{{Structure
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==X-ray Crystal Structure of Protein AGR_C_4470 from Agrobacterium tumefaciens. Northeast Structural Genomics Consortium Target AtR92.==
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|PDB= 2hqv |SIZE=350|CAPTION= <scene name='initialview01'>2hqv</scene>, resolution 2.00&Aring;
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<StructureSection load='2hqv' size='340' side='right'caption='[[2hqv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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<table><tr><td colspan='2'>[[2hqv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_fabrum_str._C58 Agrobacterium fabrum str. C58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HQV FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE= AGR_C_4470 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=358 Agrobacterium tumefaciens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3721 HugX]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hqv OCA], [https://pdbe.org/2hqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hqv RCSB], [https://www.ebi.ac.uk/pdbsum/2hqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hqv ProSAT], [https://www.topsan.org/Proteins/NESGC/2hqv TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hqv OCA], [http://www.ebi.ac.uk/pdbsum/2hqv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hqv RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q7CX01_AGRFC Q7CX01_AGRFC]
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== Evolutionary Conservation ==
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'''X-ray Crystal Structure of Protein AGR_C_4470 from Agrobacterium tumefaciens. Northeast Structural Genomics Consortium Target AtR92.'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/2hqv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hqv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
We report here the crystal structure at 2.0 A resolution of the AGR_C_4470p protein from the Gram-negative bacterium Agrobacterium tumefaciens. The protein is a tightly associated dimer, each subunit of which bears strong structural homology with the two domains of the heme utilization protein ChuS from Escherichia coli and HemS from Yersinia enterocolitica. Remarkably, the organization of the AGR_C_4470p dimer is the same as that of the two domains in ChuS and HemS, providing structural evidence that these two proteins evolved by gene duplication. However, the binding site for heme, while conserved in HemS and ChuS, is not conserved in AGR_C_4470p, suggesting that it probably has a different function. This is supported by the presence of two homologs of AGR_C_4470p in E. coli, in addition to the ChuS protein.
We report here the crystal structure at 2.0 A resolution of the AGR_C_4470p protein from the Gram-negative bacterium Agrobacterium tumefaciens. The protein is a tightly associated dimer, each subunit of which bears strong structural homology with the two domains of the heme utilization protein ChuS from Escherichia coli and HemS from Yersinia enterocolitica. Remarkably, the organization of the AGR_C_4470p dimer is the same as that of the two domains in ChuS and HemS, providing structural evidence that these two proteins evolved by gene duplication. However, the binding site for heme, while conserved in HemS and ChuS, is not conserved in AGR_C_4470p, suggesting that it probably has a different function. This is supported by the presence of two homologs of AGR_C_4470p in E. coli, in addition to the ChuS protein.
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==About this Structure==
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Crystal structure of AGR_C_4470p from Agrobacterium tumefaciens.,Vorobiev SM, Neely H, Seetharaman J, Ma LC, Xiao R, Acton TB, Montelione GT, Tong L Protein Sci. 2007 Mar;16(3):535-8. PMID:17322535<ref>PMID:17322535</ref>
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2HQV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQV OCA].
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==Reference==
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Crystal structure of AGR_C_4470p from Agrobacterium tumefaciens., Vorobiev SM, Neely H, Seetharaman J, Ma LC, Xiao R, Acton TB, Montelione GT, Tong L, Protein Sci. 2007 Mar;16(3):535-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17322535 17322535]
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[[Category: Agrobacterium tumefaciens]]
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[[Category: Single protein]]
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[[Category: Acton, T.]]
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[[Category: Cunningham, K.]]
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[[Category: Fang, Y.]]
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[[Category: Hunt, J F.]]
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[[Category: Ma, L C.]]
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[[Category: Montelione, T G.]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Neely, H.]]
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[[Category: Seetharaman, J.]]
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[[Category: Tong, L.]]
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[[Category: Vorobiev, S M.]]
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[[Category: Xiao, R.]]
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[[Category: Zhao, L.]]
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[[Category: agr_c_4470]]
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[[Category: atr92]]
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[[Category: nesg]]
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[[Category: northeast structural genomics consortium]]
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[[Category: protein structure initiative]]
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[[Category: psi-2]]
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[[Category: q7cx01_agrt5]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:34:08 2008''
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2hqv" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Agrobacterium fabrum str. C58]]
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[[Category: Large Structures]]
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[[Category: Acton T]]
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[[Category: Cunningham K]]
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[[Category: Fang Y]]
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[[Category: Hunt JF]]
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[[Category: Ma LC]]
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[[Category: Montelione TG]]
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[[Category: Neely H]]
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[[Category: Seetharaman J]]
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[[Category: Tong L]]
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[[Category: Vorobiev SM]]
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[[Category: Xiao R]]
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[[Category: Zhao L]]

Current revision

X-ray Crystal Structure of Protein AGR_C_4470 from Agrobacterium tumefaciens. Northeast Structural Genomics Consortium Target AtR92.

PDB ID 2hqv

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