244d

<StructureSection load='244d' size='340' side='right' caption='[[244d]], [[Resolution|resolution]] 1.20&Aring;' scene=''>

<table><tr><td colspan='2'>[[244d]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=244D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=244D FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=244d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=244d OCA], [http://pdbe.org/244d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=244d RCSB], [http://www.ebi.ac.uk/pdbsum/244d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=244d ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.

The high-resolution crystal structure of a parallel-stranded guanine tetraplex.,Laughlan G, Murchie AI, Norman DG, Moore MH, Moody PC, Lilley DM, Luisi B Science. 1994 Jul 22;265(5171):520-4. PMID:8036494<ref>PMID:8036494</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 244d" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Laughlan, G]]

[[Category: Lilley, D M.J]]

[[Category: Luisi, B]]

[[Category: Moody, P C.E]]

[[Category: Moore, M H]]

[[Category: Murchie, A I.H]]

[[Category: Norman, D G]]

[[Category: Unusual dna]]