1zwl

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==Structure of WrbA from Pseudomonas aeruginosa in complex with FMN==
==Structure of WrbA from Pseudomonas aeruginosa in complex with FMN==
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<StructureSection load='1zwl' size='340' side='right' caption='[[1zwl]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='1zwl' size='340' side='right'caption='[[1zwl]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1zwl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZWL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1zwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZWL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zwk|1zwk]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">wrba ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zwl OCA], [https://pdbe.org/1zwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zwl RCSB], [https://www.ebi.ac.uk/pdbsum/1zwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zwl ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1zwl TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zwl OCA], [http://pdbe.org/1zwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zwl RCSB], [http://www.ebi.ac.uk/pdbsum/1zwl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zwl ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1zwl TOPSAN]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NQOR_PSEAE NQOR_PSEAE]] It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide (By similarity).
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[https://www.uniprot.org/uniprot/NQOR_PSEAE NQOR_PSEAE] It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zw/1zwl_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zw/1zwl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Burley, S K]]
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[[Category: Large Structures]]
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[[Category: Gorman, J]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Structural genomic]]
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[[Category: Burley SK]]
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[[Category: Shapiro, L]]
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[[Category: Gorman J]]
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[[Category: Fmn]]
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[[Category: Shapiro L]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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[[Category: Protein binding]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Wrba]]
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Current revision

Structure of WrbA from Pseudomonas aeruginosa in complex with FMN

PDB ID 1zwl

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