Anthrax protective antigen

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== Function ==
== Function ==
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'''Anthrax protective antigen''' (PA) is the cell-binding part of the ''Bacillus anthracis'' anthrax toxin. The anthrax toxin is composed of the PA, lethal factor and edema factor. The PA translocates the lethal (LF) and edema factors (EF) into the cell. The 83kD form of PA (PA83) binds to the anthrax toxin receptor. A 20kD fragment (PA20) is cleaved off the PA83 and the remaining PA63 assembles into ring-shaped oligomer which becomes a membrane pre-channel. The PA pre-channel binds the lethal and edema factors allowing them to penetrate the membrane via pH gradient. For more details see [[Molecular Playground/Protective Antigen]].
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'''Anthrax protective antigen''' (PA) is the cell-binding part of the ''Bacillus anthracis'' anthrax toxin. The anthrax toxin is composed of the PA, lethal factor and edema factor. The PA translocates the [[Anthrax Lethal Factor|lethal]] (LF) and [[Anthrax edema factor|edema]] factors (EF) into the cell. The 83kD form of PA '''(PA83)''' binds to the anthrax toxin receptor. A 20kD fragment (PA20) is cleaved off the PA83 and the remaining '''PA63''' assembles into ring-shaped oligomer which becomes a membrane pre-channel. The PA pre-channel binds the lethal and edema factors allowing them to penetrate the membrane via pH gradient.
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For more details see
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*[[Molecular Playground/Protective Antigen]]<br />
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*[[Anthrax Toxin Protein]]<br />
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*[[Toxins]].
== Structural highlights ==
== Structural highlights ==
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* <scene name='48/485625/Cv/6'>Domain 4</scene> (in magenta) is important for receptor recognition and pore formation. <br />
* <scene name='48/485625/Cv/6'>Domain 4</scene> (in magenta) is important for receptor recognition and pore formation. <br />
<scene name='48/485625/Cv/11'>Click here to see Ca binding site</scene>. <ref>PMID:9039918</ref>
<scene name='48/485625/Cv/11'>Click here to see Ca binding site</scene>. <ref>PMID:9039918</ref>
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</StructureSection>
 
==3D structures of anthrax protective antigen==
==3D structures of anthrax protective antigen==
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[[Anthrax protective antigen 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*PA83
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**[[1acc]], [[3tew]], [[3q8a]], [[3q8b]], [[4h2a]] – PA<br />
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**[[3tex]], [[3tey]], [[3tez]], [[3q8c]], [[3q8e]], [[4ee2]], [[4nam]], [[5fr3]] – PA (mutant)<br />
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**[[3mhz]], [[3q8f]] – PA with fluoro-histidine<br />
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**[[1t6b]] – PA + anthrax toxin receptor A/I domain
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*PA63
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**[[3hvd]] – PA63 (mutant)<br />
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**[[1tzo]] – PA63<br />
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**[[3j9c]] – PA63 C-terminal<br />
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**[[1tzn]] – PA63 + anthrax toxin receptor VWA domain<br />
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**[[3kwv]] – PA63 (mutant) + lethal factor
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*PA domain 4
 
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**[[3ino]] – PA domain 4<br />
 
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**[[3etb]] – PA domain 4 + antibody (mutant)
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Anthrax protective antigen (PA83) complex with Ca+2 ions (PDB code 1acc)

Drag the structure with the mouse to rotate


References

  1. ↑ Petosa C, Collier RJ, Klimpel KR, Leppla SH, Liddington RC. Crystal structure of the anthrax toxin protective antigen. Nature. 1997 Feb 27;385(6619):833-8. PMID:9039918 doi:10.1038/385833a0

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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