5yx9

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'''Unreleased structure'''
 
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The entry 5yx9 is ON HOLD
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==Cryo-EM structure of human TRPC6 at 3.8A resolution==
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<SX load='5yx9' size='340' side='right' viewer='molstar' caption='[[5yx9]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5yx9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YX9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YX9 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yx9 OCA], [https://pdbe.org/5yx9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yx9 RCSB], [https://www.ebi.ac.uk/pdbsum/5yx9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yx9 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN] Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN] Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.<ref>PMID:19936226</ref> <ref>PMID:23291369</ref> <ref>PMID:26892346</ref>
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen L]]
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[[Category: Guo W]]
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[[Category: Tang Q]]

Current revision

Cryo-EM structure of human TRPC6 at 3.8A resolution

5yx9, resolution 3.80Å

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