2hxb

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[[Image:2hxb.jpg|left|200px]]
 
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{{Structure
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==dCTP deaminase-dUTPase from Methanocaldococcus jannaschii==
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|PDB= 2hxb |SIZE=350|CAPTION= <scene name='initialview01'>2hxb</scene>, resolution 2.550&Aring;
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<StructureSection load='2hxb' size='340' side='right'caption='[[2hxb]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2hxb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HXB FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/dCTP_deaminase_(dUMP-forming) dCTP deaminase (dUMP-forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.30 3.5.4.30] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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|GENE= dcd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hxb OCA], [https://pdbe.org/2hxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hxb RCSB], [https://www.ebi.ac.uk/pdbsum/2hxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hxb ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=[[1ogh|1OGH]], [[2hxd|2HXD]], [[2hxe|2HXE]]
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hxb OCA], [http://www.ebi.ac.uk/pdbsum/2hxb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hxb RCSB]</span>
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[https://www.uniprot.org/uniprot/DCDB_METJA DCDB_METJA] Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase with a lower affinity for dUTP than for dCTP.<ref>PMID:12538648</ref> <ref>PMID:12670946</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/2hxb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hxb ConSurf].
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<div style="clear:both"></div>
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'''dCTP deaminase-dUTPase from Methanocaldococcus jannaschii'''
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==See Also==
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*[[Deaminase 3D structures|Deaminase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2HXB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HXB OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Single protein]]
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[[Category: Bynck JH]]
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[[Category: dCTP deaminase (dUMP-forming)]]
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[[Category: Johansson E]]
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[[Category: Bynck, J H.]]
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[[Category: Johansson, E.]]
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[[Category: beta barrel]]
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[[Category: hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:36:44 2008''
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Current revision

dCTP deaminase-dUTPase from Methanocaldococcus jannaschii

PDB ID 2hxb

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