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| - | [[Image:2hy3.gif|left|200px]] | |
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| - | {{Structure
| + | ==Crystal structure of the human tyrosine receptor phosphate gamma in complex with vanadate== |
| - | |PDB= 2hy3 |SIZE=350|CAPTION= <scene name='initialview01'>2hy3</scene>, resolution 2.60Å
| + | <StructureSection load='2hy3' size='340' side='right'caption='[[2hy3]]' scene=''> |
| - | |SITE= <scene name='pdbsite=AC1:Vo4+Binding+Site+For+Residue+A+158'>AC1</scene> and <scene name='pdbsite=AC2:Vo4+Binding+Site+For+Residue+B+159'>AC2</scene>
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene>
| + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HY3 FirstGlance]. <br> |
| - | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hy3 OCA], [https://pdbe.org/2hy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hy3 RCSB], [https://www.ebi.ac.uk/pdbsum/2hy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hy3 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2hy3 TOPSAN]</span></td></tr> |
| - | |GENE= PTPRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
| + | </table> |
| - | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00047 PTPc], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00194 PTPc]</span>
| + | == Evolutionary Conservation == |
| - | |RELATEDENTRY=
| + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hy3 OCA], [http://www.ebi.ac.uk/pdbsum/2hy3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hy3 RCSB]</span>
| + | Check<jmol> |
| - | }}
| + | <jmolCheckbox> |
| | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/2hy3_consurf.spt"</scriptWhenChecked> |
| | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| | + | <text>to colour the structure by Evolutionary Conservation</text> |
| | + | </jmolCheckbox> |
| | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hy3 ConSurf]. |
| | + | <div style="clear:both"></div> |
| | | | |
| - | '''Crystal structure of the human tyrosine receptor phosphate gamma in complex with vanadate'''
| + | ==See Also== |
| - | | + | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] |
| - | | + | __TOC__ |
| - | ==Overview== | + | </StructureSection> |
| - | The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
| + | [[Category: Large Structures]] |
| - | | + | [[Category: Bera A]] |
| - | ==About this Structure==
| + | [[Category: Burley SK]] |
| - | 2HY3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HY3 OCA].
| + | [[Category: Freeman JC]] |
| - | | + | [[Category: Jin X]] |
| - | ==Reference==
| + | [[Category: Min T]] |
| - | Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]
| + | [[Category: Mu H]] |
| - | [[Category: Homo sapiens]]
| + | [[Category: Reyes C]] |
| - | [[Category: Protein-tyrosine-phosphatase]]
| + | [[Category: Sauder JM]] |
| - | [[Category: Single protein]] | + | [[Category: Shapiro L]] |
| - | [[Category: Bera, A.]] | + | [[Category: Smith D]] |
| - | [[Category: Burley, S K.]] | + | [[Category: Wasserman SR]] |
| - | [[Category: Freeman, J C.]] | + | |
| - | [[Category: Jin, X.]] | + | |
| - | [[Category: Min, T.]] | + | |
| - | [[Category: Mu, H.]] | + | |
| - | [[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
| + | |
| - | [[Category: Reyes, C.]] | + | |
| - | [[Category: Sauder, J M.]] | + | |
| - | [[Category: Shapiro, L.]] | + | |
| - | [[Category: Smith, D.]] | + | |
| - | [[Category: Wasserman, S R.]] | + | |
| - | [[Category: hydrolase]]
| + | |
| - | [[Category: new york structural genomix research consortium]]
| + | |
| - | [[Category: nysgxrc]]
| + | |
| - | [[Category: protein structure initiative]]
| + | |
| - | [[Category: psi]]
| + | |
| - | [[Category: structural genomic]]
| + | |
| - | [[Category: twisted mixed beta-sheets flanked by {alpha}-helice]]
| + | |
| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:37:05 2008''
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