|
|
| (One intermediate revision not shown.) |
| Line 1: |
Line 1: |
| | | | |
| | ==Structure of the cis confomer of the major extracytoplasmic domain of the bacterial cell division protein divib from geobacillus stearothermophilus== | | ==Structure of the cis confomer of the major extracytoplasmic domain of the bacterial cell division protein divib from geobacillus stearothermophilus== |
| - | <StructureSection load='2alj' size='340' side='right' caption='[[2alj]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''> | + | <StructureSection load='2alj' size='340' side='right'caption='[[2alj]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2alj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_12980 Atcc 12980]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ALJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ALJ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2alj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ALJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ALJ FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yr1|1yr1]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DivIB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 ATCC 12980])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2alj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2alj OCA], [https://pdbe.org/2alj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2alj RCSB], [https://www.ebi.ac.uk/pdbsum/2alj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2alj ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2alj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2alj OCA], [http://pdbe.org/2alj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2alj RCSB], [http://www.ebi.ac.uk/pdbsum/2alj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2alj ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/DIVIB_GEOKA DIVIB_GEOKA]] Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.[HAMAP-Rule:MF_00912] | + | [https://www.uniprot.org/uniprot/DIVIB_GEOKA DIVIB_GEOKA] Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.[HAMAP-Rule:MF_00912] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
| Line 33: |
Line 32: |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Atcc 12980]] | + | [[Category: Geobacillus stearothermophilus]] |
| - | [[Category: King, G F]] | + | [[Category: Large Structures]] |
| - | [[Category: Robson, S A]] | + | [[Category: King GF]] |
| - | [[Category: Cell cycle]] | + | [[Category: Robson SA]] |
| - | [[Category: Cell-division initiation protein]]
| + | |
| - | [[Category: Divib]]
| + | |
| - | [[Category: Divisome]]
| + | |
| - | [[Category: Ftsq]]
| + | |
| Structural highlights
Function
DIVIB_GEOKA Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.[HAMAP-Rule:MF_00912]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Bacterial cytokinesis requires the coordinated assembly of a complex of proteins, collectively known as the divisome, at the incipient division site. DivIB/FtsQ is a conserved component of the divisome in bacteria with cell walls, suggesting that it plays a role in synthesis and/or remodeling of septal peptidoglycan. We demonstrate that the extracytoplasmic region of DivIB comprises three discrete domains that we designate alpha, beta, and gamma from the N to C terminus. The alpha-domain is proximal to the cytoplasmic membrane and coincident with the polypeptide transport-associated domain that was proposed previously to function as a molecular chaperone. The beta-domain has a unique 3D fold, with no eukaryotic counterpart, and we show that it interconverts between two discrete conformations via cis-trans isomerization of a Tyr-Pro peptide bond. We propose that this isomerization might modulate protein-protein interactions of the flanking alpha- and gamma-domains. The C-terminal gamma-domain is unstructured in the absence of other divisomal proteins, but we show that it is critical for DivIB function.
Domain architecture and structure of the bacterial cell division protein DivIB.,Robson SA, King GF Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6700-5. Epub 2006 Apr 17. PMID:16618922[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Robson SA, King GF. Domain architecture and structure of the bacterial cell division protein DivIB. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6700-5. Epub 2006 Apr 17. PMID:16618922
|
