Fibrinogen

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Current revision (07:16, 28 July 2020) (edit) (undo)
 
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Shown below is a 3D printed physical model of Fibrinogen. The structure is shown as an alpha carbon backbone colored by chain, with the three chains of each copy of fibrinogen colored yellow, blue and purple.
Shown below is a 3D printed physical model of Fibrinogen. The structure is shown as an alpha carbon backbone colored by chain, with the three chains of each copy of fibrinogen colored yellow, blue and purple.
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[[Image:fibrinogen1_centerForBioMolecularModeling.jpg|550px]]
[[Image:fibrinogen1_centerForBioMolecularModeling.jpg|550px]]
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**[[2a45]] - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor<br />
**[[2a45]] - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor<br />
**[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] - hFba+hFbb+hFbg<br />
**[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] - hFba+hFbb+hFbg<br />
-
**[[1jy3]], [[1deq]] – cFba+cFbb+cFbg – cow<br />
+
**[[1jy3]], [[1deq]] – bFba+Fbb+Fbg – bovine<br />
-
**[[1jy2]] - cFba+cFbb+cFbg proteolytic fragment<br />
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**[[1jy2]] - bFba+Fbb+Fbg proteolytic fragment<br />
 +
**[[1m1j]] - cFba+Fbb+Fbg+peptide ligand – chicken<br />
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**[[1ei3]] - cFba+Fbb+Fbg<br />
**[[1n73]], [[1lwu]] - Fba+Fbb+Fbg+peptide ligand – Sea lamprey<br />
**[[1n73]], [[1lwu]] - Fba+Fbb+Fbg+peptide ligand – Sea lamprey<br />
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**[[1m1j]] - heFba+heFbb+heFbg+peptide ligand – hen<br />
 
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**[[1ei3]] - heFba+heFbb+heFbg<br />
 
*Fibrinogen α chain
*Fibrinogen α chain
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**[[1fzd]] – hFba EC domain<br />
**[[1fzd]] – hFba EC domain<br />
**[[1bbr]] – hFba+cε-thrombin<br />
**[[1bbr]] – hFba+cε-thrombin<br />
-
**[[2jor]] – cFba – NMR<br />
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**[[2jor]] – bFba – NMR<br />
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**[[2baf]] – cFba<br />
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**[[2baf]] – bFba<br />
*Fibrinogen β chain
*Fibrinogen β chain
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*Fibrinogen γ chain
*Fibrinogen γ chain
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**[[1fic]], [[1fid]] – hFbg<br />
 +
**[[3fib]] – hFbg C terminal<br />
**[[2vr3]] – hFbg+SaClumping Factor A – ''Staphylococcus aureus''<br />
**[[2vr3]] – hFbg+SaClumping Factor A – ''Staphylococcus aureus''<br />
-
**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains<br />
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**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+ antibody <br />
**[[2fib]], [[3fib]] - hFbg+peptide ligand<br />
**[[2fib]], [[3fib]] - hFbg+peptide ligand<br />
**[[1fib]] – hFbg+Ca<br />
**[[1fib]] – hFbg+Ca<br />
-
**[[1fic]], [[1fid]] – hFbg<br />
 
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**[[3fib]] – hFbg C terminal<br />
 
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**[[1dug]] – Fbg C-terminal/glutathione S-transferase – ''Schistosoma japonicum''<br />
 
**[[2hwl]] – hFbg peptide+prothrombin<br />
**[[2hwl]] – hFbg peptide+prothrombin<br />
**[[2y7l]] – hFbg + agglutinin-like protein <br />
**[[2y7l]] – hFbg + agglutinin-like protein <br />
 +
**[[1dug]] – Fbg C-terminal/glutathione S-transferase – ''Schistosoma japonicum''<br />
}}
}}
==References==
==References==

Current revision

Crystal structure of glycosylated fibrinogen fragment D. Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion (PDB code 1n73)

Drag the structure with the mouse to rotate

3D Structure of Fibrinogen

Updated on 28-July-2020

References

  1. ↑ Betts L, Merenbloom BK, Lord ST. The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE. J Thromb Haemost. 2006 May;4(5):1139-41. PMID:16689770 doi:10.1111/j.1538-7836.2006.01902.x
  2. ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, David Canner, Mark Hoelzer, Alexander Berchansky, Angel Herraez

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