This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Elastase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:17, 18 June 2019) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
<StructureSection load='1eai' size='350' side='right' caption='Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow) (PDB code [[1eai]]).' scene='41/411401/Cv/3'>
<StructureSection load='1eai' size='350' side='right' caption='Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow) (PDB code [[1eai]]).' scene='41/411401/Cv/3'>
-
[[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins. The ELAs are numbered according to their genes. '''Panceatic ELA''' cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. <ref>PMID:12059069</ref> For additional details see [[Serine Proteases]].
+
[[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins. The ELAs are numbered according to their genes. '''Panceatic ELA''' cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. <ref>PMID:12059069</ref> For additional details see <br />
 +
*[[Protease]]<br />
 +
*[[Serine Proteases]].
== Relevance ==
== Relevance ==
-
'''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation.
+
'''ELA1''' in the pancreas correlates well with exocrine pancreatic functioning and is used as a function test for patients with pancreatitis. '''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation.
== Disease ==
== Disease ==
Line 13: Line 15:
== Structural highlights ==
== Structural highlights ==
-
<scene name='41/411401/Cv/6'>Pig elastase</scene> (cyan, green) complex with <scene name='41/411401/Cv/5'>chymotrypsin/elastase isoinhibitor</scene> (magenta, yellow) (PDB code [[1eai]]). ELA <scene name='41/411401/Cv/7'>catalytic triad is Ser-His-Asp</scene>.<ref>PMID:7922044</ref>
+
<scene name='41/411401/Cv/8'>Pig elastase</scene> (cyan, green) complex with <scene name='41/411401/Cv/9'>chymotrypsin/elastase isoinhibitor</scene> (magenta, yellow) (PDB code [[1eai]]). ELA <scene name='41/411401/Cv/10'>catalytic triad is Ser-His-Asp</scene>.<ref>PMID:7922044</ref>
-
</StructureSection>
+
 
==3D structures of elastase==
==3D structures of elastase==
 +
[[Elastase 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
* MMP12 See [[Matrix metalloproteinase]]
+
-
 
+
-
* MMP16 See [[Matrix metalloproteinase]]
+
-
 
+
-
* ELA1
+
-
 
+
-
**[[3mty]], [[3mu0]], [[3mu1]], [[3mu4]], [[3mu5]], [[3mu8]], [[3mnb]], [[3mnc]], [[3mns]], [[3mnx]], [[3mo3]], [[3mo6]], [[3mo9]], [[3moc]], [[3e3t]], [[2v0b]], [[2g4t]], [[2g4u]], [[2de8]], [[2blo]], [[2blq]], [[2a7c]], [[2a7j]], [[1gvk]], [[1qnj]], [[1lvy]], [[3est]], [[1est]], [[2oqu]], [[3odd]], [[3odf]], [[2bdc]] – pELA1 – pig<br />
+
-
**[[3hgn]] – pELA1+peptidyl inhibitor – neutron<br />
+
-
**[[3hgp]], [[2cv3]], [[2bdb]], [[2bcd]], [[2h1u]], [[1mmj]], [[1h9l]], [[1nes]], [[4est]], [[5est]], [[8est]], [[7est]], [[6est]] - pELA1+peptidyl inhibitor<br />
+
-
**[[1fzz]] – pELA1+ONO-6818<br />
+
-
**[[1qr3]], [[1qgf]], [[1bru]], [[1hv7]], [[1btu]] – pELA1+cyclic inhibitor<br />
+
-
**[[1okx]] – pELA1 + scyptolin<br />
+
-
**[[1e34]], [[1e35]], [[1e36]], [[1e37]], [[1e38]] – pELA1-gamma-lactam<br />
+
-
**[[1eai]] – pELA1+Ascaris inhibitor<br />
+
-
**[[2d26]] – pELA1+α-1-antitrypsin<br />
+
-
**[[1fle]] – pELA1+elafin<br />
+
-
**[[1b0e]], [[1b0f]] – pELA1+MDL<br />
+
-
**[[2v35]] – pELA1+JM54<br />
+
-
**[[2iot]] – pELA1+clavulanic acid<br />
+
-
**[[2de9]] – pELA1+tris<br />
+
-
**[[1uvo]], [[1uvp]], [[1lka]], [[1lkb]] – pELA1+ions<br />
+
-
**[[1gwa]] – pELA1+I3<br />
+
-
**[[1uo6]], [[1c1m]] – pELA1+Xe<br />
+
-
**[[1l0z]], [[1l1g]] - pELA1+Xe+Br<br />
+
-
**[[2bb4]], [[2bd2]], [[2bd3]], [[2bd4]], [[2bd5]], [[2bd7]], [[2bd8]], [[2bd9]], [[1hax]], [[1hay]], [[1haz]], [[1hb0]], [[1qix]] – pELA1+beta-casomorphin-7<br />
+
-
**[[2bda]] – pELA1+N-acetyl-NPI<br />
+
-
**[[1mcv]] – pELA1+squash inhibitor<br />
+
-
**[[1bma]] – pELA1+aminimide<br />
+
-
**[[1elf]], [[1elg]] – pELA1+peptidyl hydroxylamine<br />
+
-
**[[1eld]], [[1ele]], [[1elb]], [[1ela]], [[1elc]], [[2est]] – pELA1+anilide inhibitor<br />
+
-
**[[1esa]], [[1esb]] – pELA1 intermediate<br />
+
-
**[[1eas]], [[1eat]], [[1eau]] – pELA1+pyridine inhibitor<br />
+
-
**[[1inc]] – pELA1+benzoxazinone<br />
+
-
**[[1jim]], [[9est]], [[8est]] – pELA1+coumarin derivative<br />
+
-
**[[2fo9]], [[2foa]], [[2fob]], [[2foc]], [[2fod]], [[2foe]], [[2fof]], [[2fog]], [[2foh]] – pELA1+solvent<br />
+
-
**[[4k89]], [[1ezm]] – PaELA – ''Pseudomonas aeruginosa''<br />
+
-
**[[3dbk]] – PaELA+phophoramidon <br />
+
-
**[[1u4g]] – PaELA+HPI<br />
+
-
**[[6f8b]] – PaELA + inhibitor<br />
+
-
**[[1elt]] – ELA - salmon<br />
+
-
 
+
-
* ELA2 or neutrophil elastase
+
-
 
+
-
**[[3q76]] – hELA2<br />
+
-
**[[3q77]] – hELA2+dihydropyrimidone inhibitor<br />
+
-
**[[2z7f]] – hELA2 peptidase domain +antileukoproteinase<br />
+
-
**[[2rg3]] – hELA2+sulfonic inhibitor<br />
+
-
**[[1h1b]], [[1ppg]], [[1hne]], [[5a09]], [[5a0a]], [[5a0b]], [[5a0c]], [[5a8x]], [[5a8y]], [[5a8z]], [[5abw]] – hELA2+inhibitor<br />
+
-
**[[1ppf]] – hELA2+ovomucoid<br />
+
-
**[[1b0f]] – hELA2+MDL101146<br />
+
-
**[[4nzl]] – hELA2 + protein <br />
+
-
**[[4wvp]] – hELA2 + activity-based probe <br />
+
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow) (PDB code 1eai).

Drag the structure with the mouse to rotate

References

  1. ↑ Dominici R, Franzini C. Fecal elastase-1 as a test for pancreatic function: a review. Clin Chem Lab Med. 2002 Apr;40(4):325-32. PMID:12059069 doi:http://dx.doi.org/10.1515/CCLM.2002.051
  2. ↑ Huang K, Strynadka NC, Bernard VD, Peanasky RJ, James MN. The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase. Structure. 1994 Jul 15;2(7):679-89. PMID:7922044

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Guido Hansen, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Elastase"
Personal tools