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2i3y

From Proteopedia

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[[Image:2i3y.gif|left|200px]]
 
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{{Structure
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==Crystal structure of human glutathione peroxidase 5==
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|PDB= 2i3y |SIZE=350|CAPTION= <scene name='initialview01'>2i3y</scene>, resolution 2.00&Aring;
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<StructureSection load='2i3y' size='340' side='right'caption='[[2i3y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
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<table><tr><td colspan='2'>[[2i3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I3Y FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE= GPX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i3y OCA], [https://pdbe.org/2i3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i3y RCSB], [https://www.ebi.ac.uk/pdbsum/2i3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i3y ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i3y OCA], [http://www.ebi.ac.uk/pdbsum/2i3y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i3y RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/GPX5_HUMAN GPX5_HUMAN] Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/2i3y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i3y ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of human glutathione peroxidase 5'''
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==See Also==
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*[[Glutathione peroxidase|Glutathione peroxidase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2I3Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I3Y OCA].
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[[Category: Glutathione peroxidase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bunkoczi G]]
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[[Category: Delft, F Von.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Johansson C]]
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[[Category: Johansson, C.]]
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[[Category: Kavanagh KL]]
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[[Category: Kavanagh, K L.]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U.]]
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[[Category: Rojkova A]]
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[[Category: Rojkova, A.]]
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[[Category: Sundstrom M]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Umeano C]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Umeano, C.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: epididymal androgen related protein]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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[[Category: thioredoxin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:39:18 2008''
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Current revision

Crystal structure of human glutathione peroxidase 5

PDB ID 2i3y

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