This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6dd3
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6dd3 is ON HOLD Authors: Forouhar, F., Dieck, C.L., Tzoneva, G., Carpenter, Z., Ambesi-Impiombato, A., Sanchez-Martin, M., Kirschner-Schwabe, R., Le...) |
|||
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state== | |
| - | + | <StructureSection load='6dd3' size='340' side='right'caption='[[6dd3]], [[Resolution|resolution]] 1.98Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6dd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DD3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd3 OCA], [https://pdbe.org/6dd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dd3 RCSB], [https://www.ebi.ac.uk/pdbsum/6dd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd3 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Sanchez-Martin | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Ambesi-Impiombato A]] | ||
| + | [[Category: Carpenter Z]] | ||
| + | [[Category: Dieck CL]] | ||
| + | [[Category: Ferrando AA]] | ||
| + | [[Category: Forouhar F]] | ||
| + | [[Category: Kirschner-Schwabe R]] | ||
| + | [[Category: Lew S]] | ||
| + | [[Category: Sanchez-Martin M]] | ||
| + | [[Category: Seetharaman J]] | ||
| + | [[Category: Tong L]] | ||
| + | [[Category: Tzoneva G]] | ||
Current revision
Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state
| |||||||||||
