6dd3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state== | |
| - | + | <StructureSection load='6dd3' size='340' side='right'caption='[[6dd3]], [[Resolution|resolution]] 1.98Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6dd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DD3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd3 OCA], [https://pdbe.org/6dd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dd3 RCSB], [https://www.ebi.ac.uk/pdbsum/6dd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd3 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Sanchez-Martin | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Ambesi-Impiombato A]] | ||
| + | [[Category: Carpenter Z]] | ||
| + | [[Category: Dieck CL]] | ||
| + | [[Category: Ferrando AA]] | ||
| + | [[Category: Forouhar F]] | ||
| + | [[Category: Kirschner-Schwabe R]] | ||
| + | [[Category: Lew S]] | ||
| + | [[Category: Sanchez-Martin M]] | ||
| + | [[Category: Seetharaman J]] | ||
| + | [[Category: Tong L]] | ||
| + | [[Category: Tzoneva G]] | ||
Current revision
Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state
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