6ghj
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6ghj is ON HOLD until Paper Publication Authors: Martinez Molledo, M., Quistgaard, E.M., Loew, C. Description: PepTSt in complex with tripeptide Ph...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==PepTSt in complex with tripeptide Phe-Ala-Gln== | |
| + | <StructureSection load='6ghj' size='340' side='right' caption='[[6ghj]], [[Resolution|resolution]] 2.26Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ghj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strt2 Strt2] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GHJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=78M:(2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE'>78M</scene>, <scene name='pdbligand=78N:(2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE'>78N</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dtpT, stu0970 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264199 STRT2])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ghj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ghj OCA], [http://pdbe.org/6ghj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ghj RCSB], [http://www.ebi.ac.uk/pdbsum/6ghj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ghj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Proton-dependent oligopeptide transporters (POTs) are important for uptake of di-/tripeptides in many organisms and for drug transport in humans. The binding mode of dipeptides has been well described. However, it is still debated how tripeptides are recognized. Here, we show that tripeptides of the sequence Phe-Ala-Xxx bind with similar affinities as dipeptides to the POT transporter from Streptococcus thermophilus (PepTSt ). We furthermore determined a 2.3-A structure of PepTSt in complex with Phe-Ala-Gln. The phenylalanine and alanine residues of the peptide adopt the same positions as previously observed for the Phe-Ala dipeptide, while the glutamine side chain extends into a hitherto uncharacterized pocket. This pocket is adaptable in size and can likely accommodate a wide variety of peptide side chains. This article is protected by copyright. All rights reserved. | ||
| - | + | Tripeptide binding in a Proton-Dependent Oligopeptide Transporter.,Martinez Molledo M, Quistgaard EM, Low C FEBS Lett. 2018 Sep 8. doi: 10.1002/1873-3468.13246. PMID:30194725<ref>PMID:30194725</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6ghj" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Symporter|Symporter]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Strt2]] | ||
| + | [[Category: Synthetic construct sequences]] | ||
[[Category: Loew, C]] | [[Category: Loew, C]] | ||
| - | [[Category: | + | [[Category: Molledo, M Martinez]] |
| - | [[Category: | + | [[Category: Quistgaard, E M]] |
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Mf]] | ||
| + | [[Category: Peptide transporter]] | ||
| + | [[Category: Pot]] | ||
Current revision
PepTSt in complex with tripeptide Phe-Ala-Gln
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