5oeq

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==Mycobacterium tuberculosis DprE1 in complex with inhibitor TCA020==
==Mycobacterium tuberculosis DprE1 in complex with inhibitor TCA020==
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<StructureSection load='5oeq' size='340' side='right' caption='[[5oeq]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='5oeq' size='340' side='right'caption='[[5oeq]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5oeq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OEQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5oeq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OEQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=P95:~{N}-[3-(pyrimidin-2-ylcarbamoyl)thiophen-2-yl]-[1,3]thiazolo[4,5-c]pyridine-2-carboxamide'>P95</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kw5|4kw5]], [[5oel|5oel]], [[5oep|5oep]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=P95:~{N}-[3-(pyrimidin-2-ylcarbamoyl)thiophen-2-yl]-[1,3]thiazolo[4,5-c]pyridine-2-carboxamide'>P95</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oeq OCA], [http://pdbe.org/5oeq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oeq RCSB], [http://www.ebi.ac.uk/pdbsum/5oeq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oeq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5oeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oeq OCA], [https://pdbe.org/5oeq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5oeq RCSB], [https://www.ebi.ac.uk/pdbsum/5oeq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5oeq ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Batt, S M]]
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[[Category: Large Structures]]
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[[Category: Besra, G S]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Futterer, K]]
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[[Category: Batt SM]]
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[[Category: Fad-containing oxidoreductase decaprenylphosphoarabinose synthesis]]
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[[Category: Besra GS]]
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[[Category: Oxidoreductase]]
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[[Category: Futterer K]]

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Mycobacterium tuberculosis DprE1 in complex with inhibitor TCA020

PDB ID 5oeq

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