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5i90

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==Crystal Structure of PvdN from Pseudomonas Aeruginosa==
==Crystal Structure of PvdN from Pseudomonas Aeruginosa==
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<StructureSection load='5i90' size='340' side='right' caption='[[5i90]], [[Resolution|resolution]] 1.22&Aring;' scene=''>
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<StructureSection load='5i90' size='340' side='right'caption='[[5i90]], [[Resolution|resolution]] 1.22&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5i90]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I90 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5i90]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I90 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.219&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pvdN, PA2394 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i90 OCA], [http://pdbe.org/5i90 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i90 RCSB], [http://www.ebi.ac.uk/pdbsum/5i90 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i90 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i90 OCA], [https://pdbe.org/5i90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i90 RCSB], [https://www.ebi.ac.uk/pdbsum/5i90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i90 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/G3XCY5_PSEAE G3XCY5_PSEAE]
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The Gram-negative pathogen Pseudomonas aeruginosa uses a nonribosomal peptide synthetase (NRPS) biosynthetic cluster for the production of a peptide siderophore. In addition to four multimodular NRPS proteins, the biosynthetic pathway also requires several additional enzymes involved in the production of nonproteinogenic amino acids and maturation of the peptide product. Among the proteins that are required for the final steps in pyoverdine synthesis is PvdN, a pyridoxal phosphate-dependent enzyme that catalyzes an uncharacterized step in pyoverdine production. This study reports the high-resolution structure of PvdN bound to a PLP cofactor solved by multi-wavelength anomalous dispersion (MAD). The PvdN model shows high structural homology to type I aspartate aminotransferases and also contains positive density that suggests an uncharacterized external aldimine.
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1.2 A resolution crystal structure of the periplasmic aminotransferase PvdN from Pseudomonas aeruginosa.,Drake EJ, Gulick AM Acta Crystallogr F Struct Biol Commun. 2016 May;72(Pt 5):403-8. doi:, 10.1107/S2053230X16006257. Epub 2016 Apr 22. PMID:27139833<ref>PMID:27139833</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5i90" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pseae]]
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[[Category: Large Structures]]
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[[Category: Drake, E J]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Gulick, A M]]
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[[Category: Drake EJ]]
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[[Category: Pyoverdine plp aminotransferase]]
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[[Category: Gulick AM]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of PvdN from Pseudomonas Aeruginosa

PDB ID 5i90

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