2i7q

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[[Image:2i7q.gif|left|200px]]
 
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{{Structure
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==Crystal structure of Human Choline Kinase A==
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|PDB= 2i7q |SIZE=350|CAPTION= <scene name='initialview01'>2i7q</scene>, resolution 1.900&Aring;
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<StructureSection load='2i7q' size='340' side='right'caption='[[2i7q]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>
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<table><tr><td colspan='2'>[[2i7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I7Q FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE= CHKA, CHK, CKI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7q OCA], [https://pdbe.org/2i7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i7q RCSB], [https://www.ebi.ac.uk/pdbsum/2i7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7q ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7q OCA], [http://www.ebi.ac.uk/pdbsum/2i7q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i7q RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i7/2i7q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i7q ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of Human Choline Kinase A'''
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==See Also==
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*[[Choline kinase 3D structures|Choline kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2I7Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7Q OCA].
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__TOC__
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[[Category: Choline kinase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Landry, R.]]
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[[Category: Landry R]]
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[[Category: Nedyalkova, L.]]
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[[Category: Nedyalkova L]]
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[[Category: Park, H.]]
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[[Category: Park H]]
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[[Category: Rabeh, W M.]]
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[[Category: Rabeh WM]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Tempel W]]
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[[Category: Tempel, W.]]
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[[Category: Wasney G]]
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[[Category: Wasney, G.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: choline kinase]]
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[[Category: non-protein kinase]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:40:49 2008''
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Current revision

Crystal structure of Human Choline Kinase A

PDB ID 2i7q

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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