2bq1

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==Ribonucleotide reductase class 1b holocomplex R1E,R2F from Salmonella typhimurium==
==Ribonucleotide reductase class 1b holocomplex R1E,R2F from Salmonella typhimurium==
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<StructureSection load='2bq1' size='340' side='right' caption='[[2bq1]], [[Resolution|resolution]] 3.99&Aring;' scene=''>
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<StructureSection load='2bq1' size='340' side='right'caption='[[2bq1]], [[Resolution|resolution]] 3.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2bq1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQ1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2bq1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BQ1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGT:2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>DGT</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.99&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pem|1pem]], [[1peo|1peo]], [[1peq|1peq]], [[1peu|1peu]], [[1r2f|1r2f]], [[2r2f|2r2f]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGT:2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>DGT</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq1 OCA], [https://pdbe.org/2bq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bq1 RCSB], [https://www.ebi.ac.uk/pdbsum/2bq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bq1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq1 OCA], [http://pdbe.org/2bq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bq1 RCSB], [http://www.ebi.ac.uk/pdbsum/2bq1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bq1 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RIR4_SALTY RIR4_SALTY]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2F contains the tyrosyl radical required for catalysis.
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[https://www.uniprot.org/uniprot/RIR3_SALTY RIR3_SALTY] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1E contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/2bq1_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/2bq1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Ribonucleotide reductase|Ribonucleotide reductase]]
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*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ribonucleoside-diphosphate reductase]]
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[[Category: Large Structures]]
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[[Category: Domkin, V]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Farnegardh, M]]
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[[Category: Domkin V]]
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[[Category: Uhlin, U]]
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[[Category: Farnegardh M]]
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[[Category: Uppsten, M]]
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[[Category: Uhlin U]]
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[[Category: Allosteric enzyme]]
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[[Category: Uppsten M]]
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[[Category: Allosteric regulation]]
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[[Category: Asymmetric complex]]
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[[Category: Atp-binding]]
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[[Category: Class 1b]]
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[[Category: Dna replication]]
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[[Category: Holocomplex]]
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[[Category: Iron]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Oxidoreductase]]
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[[Category: R1]]
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[[Category: R1e]]
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[[Category: R2]]
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[[Category: R2f]]
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[[Category: Radical transfer]]
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[[Category: Ribonucleotide reductase]]
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Current revision

Ribonucleotide reductase class 1b holocomplex R1E,R2F from Salmonella typhimurium

PDB ID 2bq1

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