2brs

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==EMBP Heparin complex==
==EMBP Heparin complex==
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<StructureSection load='2brs' size='340' side='right' caption='[[2brs]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='2brs' size='340' side='right'caption='[[2brs]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2brs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BRS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2brs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BRS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IDU:2-O-SULFO-BETA-L-ALTROPYRANURONIC+ACID'>IDU</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h8u|1h8u]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDU:2-O-SULFO-BETA-L-ALTROPYRANURONIC+ACID'>IDU</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2brs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2brs OCA], [http://pdbe.org/2brs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2brs RCSB], [http://www.ebi.ac.uk/pdbsum/2brs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2brs ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2brs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2brs OCA], [https://pdbe.org/2brs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2brs RCSB], [https://www.ebi.ac.uk/pdbsum/2brs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2brs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PRG2_HUMAN PRG2_HUMAN]] Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.<ref>PMID:10913121</ref>
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[https://www.uniprot.org/uniprot/PRG2_HUMAN PRG2_HUMAN] Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.<ref>PMID:10913121</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/2brs_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/2brs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acharya, K R]]
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[[Category: Large Structures]]
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[[Category: Gleich, G J]]
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[[Category: Acharya KR]]
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[[Category: Katsamba, P S]]
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[[Category: Gleich GJ]]
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[[Category: Myszka, D G]]
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[[Category: Katsamba PS]]
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[[Category: Ohnuki, L E]]
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[[Category: Myszka DG]]
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[[Category: Swaminathan, G J]]
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[[Category: Ohnuki LE]]
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[[Category: Antibiotic]]
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[[Category: Swaminathan GJ]]
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[[Category: Embp]]
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[[Category: Eosinophil]]
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[[Category: Eosinophil granule protein]]
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[[Category: Glycoprotein]]
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[[Category: Heparin]]
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[[Category: Heparin-binding]]
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[[Category: Immune response]]
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[[Category: Lectin]]
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[[Category: Proteoglycan]]
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Current revision

EMBP Heparin complex

PDB ID 2brs

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