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2boc

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==Potassium channel KcsA-Fab complex in thallium with tetraethylarsonium (TEAs)==
==Potassium channel KcsA-Fab complex in thallium with tetraethylarsonium (TEAs)==
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<StructureSection load='2boc' size='340' side='right' caption='[[2boc]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
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<StructureSection load='2boc' size='340' side='right'caption='[[2boc]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2boc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2boc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BOC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=T1A:TETRAETHYLARSONIUM+ION'>T1A</scene>, <scene name='pdbligand=TL:THALLIUM+(I)+ION'>TL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bl8|1bl8]], [[1f6g|1f6g]], [[1j95|1j95]], [[1jq1|1jq1]], [[1jq2|1jq2]], [[1jvm|1jvm]], [[1k4c|1k4c]], [[1k4d|1k4d]], [[1r3i|1r3i]], [[1r3j|1r3j]], [[1r3k|1r3k]], [[1r3l|1r3l]], [[1s5h|1s5h]], [[2bob|2bob]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=T1A:TETRAETHYLARSONIUM+ION'>T1A</scene>, <scene name='pdbligand=TL:THALLIUM+(I)+ION'>TL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2boc OCA], [http://pdbe.org/2boc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2boc RCSB], [http://www.ebi.ac.uk/pdbsum/2boc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2boc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2boc OCA], [https://pdbe.org/2boc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2boc RCSB], [https://www.ebi.ac.uk/pdbsum/2boc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2boc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
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[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Potassium Channel|Potassium Channel]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Actinomyces lividans krasil'nikov et al. 1965]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Focia, P J]]
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[[Category: Streptomyces lividans]]
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[[Category: Gross, A]]
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[[Category: Focia PJ]]
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[[Category: Lenaeus, M J]]
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[[Category: Gross A]]
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[[Category: Vamvouka, M]]
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[[Category: Lenaeus MJ]]
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[[Category: Immune system-transport protein complex]]
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[[Category: Vamvouka M]]
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[[Category: Immune system/transport protein]]
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[[Category: Ion transport]]
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[[Category: Ionic channel]]
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[[Category: Potassium channel]]
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[[Category: Protein- antibody fab complex]]
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Current revision

Potassium channel KcsA-Fab complex in thallium with tetraethylarsonium (TEAs)

PDB ID 2boc

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