Exosome

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<StructureSection load='2je6' size='340' side='right' caption='Exosome complex containing exonuclease 1 (green), exonuclease 2 (grey) and exosome complex RNA-binding protein 1 (wheat) complex with PEG400 (pdb code [[2je6]]).' scene=''>
<StructureSection load='2je6' size='340' side='right' caption='Exosome complex containing exonuclease 1 (green), exonuclease 2 (grey) and exosome complex RNA-binding protein 1 (wheat) complex with PEG400 (pdb code [[2je6]]).' scene=''>
The '''Exosome complex''' (or just- Exosome) is a multi-protein complex capable of degrading various types of RNA molecules. The Exosome complex is found in eukaryotic cell, and also in archaea, while in bacteria it is found as a simpler complex (but it has the same function). <ref>http://en.wikipedia.org/wiki/Exosome_complex#Structure</ref>
The '''Exosome complex''' (or just- Exosome) is a multi-protein complex capable of degrading various types of RNA molecules. The Exosome complex is found in eukaryotic cell, and also in archaea, while in bacteria it is found as a simpler complex (but it has the same function). <ref>http://en.wikipedia.org/wiki/Exosome_complex#Structure</ref>
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Some of the exosome components are:<br />
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*'''MTR3''' and '''SKI6''' are part of RNase PH domain-containing subunits proposed to form a central channel which threads RNA for degradation.<br />
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*'''MTR4''' interacts with Nop53 and together they have a role in the maturation of 5.8S rRNA<ref>PMID:28883156</ref>.<br />
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*'''Rrp6''' is a nuclear-specific subunit promoting cell survival during heat stress<ref>PMID:32521279</ref>.<br />
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*'''Rrp44''' is the catalytic subunit <ref>PMID:19060898</ref>.<br />
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*'''Csl4''' is required for mRNA decay.<br />
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*'''M-phase phosphoprotein 6''' is involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA.
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You can also view the complex in a <scene name="/12/3456/Sample/2">ribbon view</scene>.
You can also view the complex in a <scene name="/12/3456/Sample/2">ribbon view</scene>.
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</StructureSection>
 
==3D structures of exosome==
==3D structures of exosome==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Exosome 3D structures]]
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Exosome
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</StructureSection>
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**[[2je6]], [[2br2]] – SsRRP4 + RRP41 + RRP42 – Sulfolobus solfataricus <br />
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**[[2jeb]] - SsRRP4 + RRP41 + RRP42 + exonuclease 1 + RNA-binding protein 1 + Mn<br />
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**[[2ba0]] – AfRRP4 + RRP41 + RRP42 – Archaeoglobus fulgidus<br />
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**[[2ba1]] – AfCSL4 + RRP41 + RRP42 <br />
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**[[2nn6]] – hCSL4 + RRP40 + RRP41 + RRP42 + RRP43 + RRP44 + RRP45 + RRP46 + RRP4 + MTR3 - human<br />
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**[[2hbj]], [[2hbk]] – yRRP6 (mutant) - yeast<br />
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**[[2ja9]] – yRRP6 <br />
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**[[2hbl]], [[2hbm]] – yRRP6 (mutant) + nucleotide<br />
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**[[4wfc]] – yRRP6 +RRP47 <br />
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**[[4wfd]] – yRRP6 +RRP47 + MTR4<br />
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**[[2wp8]] – yRRP45 + SKI6 + DIS3<br />
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**[[5okz]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + SKI6 + MTR3 + M-phase phosphoprotein 6 <br />
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**[[5g06]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + RRP6 + SKI6 + MTR3 + superkiller protein 7 + DIS3 <br />
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**[[2cpr]] – hRRP6 HRDC domain – NMR<br />
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**[[3saf]], [[3sag]], [[3sah]] – hRRP6 catalytic domain (mutant)<br />
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*Exosome complex with RNA
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**[[2jea]] - SsRRP4 + RRP41 + RRP42 + exonuclease 1 + RNA-binding protein 1 + RNA<br />
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**[[3m7n]] – AfCSL4 + RRP41 + RRP42 + RNA<br />
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**[[2m85]] – AfCSL4 + RRP41 (mutant) + RRP42 (mutant) + RNA<br />
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**[[2vnu]], [[5c0y]] – yRRP6 + RNA<br />
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**[[4ifd]] – yCSL4 + RRP40 + RRP41 + RRP42 + RRP43 + RRP44 + RRP45 + RRP46 + RRP4 + MTR3 + RNA <br />
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**[[4oo1]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + RRP6 + SKI6 + MTR3 + RNA <br />
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**[[5vzj]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + RRP6 + SKI6 + MTR3 + M-phase phosphoprotein 6 + DIS3 + RNA <br />
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**[[5k36]], [[5c0x]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + RRP6 + SKI6 + MTR3 + DIS3 + RNA <br />
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**[[5jea]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + RRP6 + SKI6 + MTR3 + superkiller protein 7 + DIS3 + RNA <br />
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**[[5jea]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + RRP6 + SKI6 + MTR3 + LRP1 + RNA <br />
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}}
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== References ==
== References ==
<references/>
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

Exosome

Exosome complex containing exonuclease 1 (green), exonuclease 2 (grey) and exosome complex RNA-binding protein 1 (wheat) complex with PEG400 (pdb code 2je6).

Drag the structure with the mouse to rotate

References

  1. ↑ http://en.wikipedia.org/wiki/Exosome_complex#Structure
  2. ↑ Falk S, Tants JN, Basquin J, Thoms M, Hurt E, Sattler M, Conti E. Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the pre-ribosomal protein Nop53. RNA. 2017 Sep 7. pii: rna.062901.117. doi: 10.1261/rna.062901.117. PMID:28883156 doi:http://dx.doi.org/10.1261/rna.062901.117
  3. ↑ Wang C, Liu Y, DeMario SM, Mandric I, Gonzalez-Figueroa C, Chanfreau GF. Rrp6 Moonlights in an RNA Exosome-Independent Manner to Promote Cell Survival and Gene Expression during Stress. Cell Rep. 2020 Jun 9;31(10):107754. PMID:32521279 doi:10.1016/j.celrep.2020.107754
  4. ↑ Schaeffer D, Tsanova B, Barbas A, Reis FP, Dastidar EG, Sanchez-Rotunno M, Arraiano CM, van Hoof A. The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities. Nat Struct Mol Biol. 2009 Jan;16(1):56-62. doi: 10.1038/nsmb.1528. Epub 2008 Dec , 7. PMID:19060898 doi:http://dx.doi.org/10.1038/nsmb.1528

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