6cq7
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The SH3 domain of MLK3 in complex with poly-proline peptide derived from Htt== |
| + | <StructureSection load='6cq7' size='340' side='right'caption='[[6cq7]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6cq7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CQ7 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cq7 OCA], [https://pdbe.org/6cq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cq7 RCSB], [https://www.ebi.ac.uk/pdbsum/6cq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cq7 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/M3K11_HUMAN M3K11_HUMAN] Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.<ref>PMID:12529434</ref> <ref>PMID:15258589</ref> <ref>PMID:8195146</ref> <ref>PMID:9003778</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Kall | + | __TOC__ |
| - | [[Category: Lavie | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kall SL]] | ||
| + | [[Category: Lavie A]] | ||
Current revision
The SH3 domain of MLK3 in complex with poly-proline peptide derived from Htt
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