2igb

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[[Image:2igb.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of PyrR, The Regulator Of The Pyrimidine Biosynthetic Operon In Bacillus caldolyticus, UMP-bound form==
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|PDB= 2igb |SIZE=350|CAPTION= <scene name='initialview01'>2igb</scene>, resolution 1.68&Aring;
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<StructureSection load='2igb' size='340' side='right'caption='[[2igb]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=U5P:URIDINE-5&#39;-MONOPHOSPHATE'>U5P</scene>
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<table><tr><td colspan='2'>[[2igb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_caldolyticus Bacillus caldolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IGB FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Uracil_phosphoribosyltransferase Uracil phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.9 2.4.2.9] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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|GENE= pyrR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1394 Bacillus caldolyticus])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2igb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igb OCA], [https://pdbe.org/2igb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2igb RCSB], [https://www.ebi.ac.uk/pdbsum/2igb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2igb ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1non|1NON]], [[1xz8|1XZ8]], [[1xzn|1XZN]], [[1a3c|1A3C]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2igb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igb OCA], [http://www.ebi.ac.uk/pdbsum/2igb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2igb RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PYRR_BACCL PYRR_BACCL] Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (Probable). Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ig/2igb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2igb ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of PyrR, The Regulator Of The Pyrimidine Biosynthetic Operon In Bacillus caldolyticus, UMP-bound form'''
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==See Also==
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2IGB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_caldolyticus Bacillus caldolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGB OCA].
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[[Category: Large Structures]]
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[[Category: Bacillus caldolyticus]]
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[[Category: Chander P]]
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[[Category: Single protein]]
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[[Category: Smith JL]]
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[[Category: Uracil phosphoribosyltransferase]]
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[[Category: Switzer RL]]
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[[Category: Chander, P.]]
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[[Category: Smith, J L.]]
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[[Category: Switzer, R L.]]
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[[Category: attenuation protein]]
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[[Category: prtase]]
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[[Category: pyrimidine biosynthesis]]
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[[Category: rna-binding]]
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[[Category: transcription]]
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[[Category: transcription regulation]]
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[[Category: transferase]]
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[[Category: uracil phosphoribosyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:43:55 2008''
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Current revision

Crystal Structure of PyrR, The Regulator Of The Pyrimidine Biosynthetic Operon In Bacillus caldolyticus, UMP-bound form

PDB ID 2igb

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