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2iyo

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==Structural characterization of a bacterial 6PDH reveals aspects of specificity, mechanism and mode of inhibition==
==Structural characterization of a bacterial 6PDH reveals aspects of specificity, mechanism and mode of inhibition==
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<StructureSection load='2iyo' size='340' side='right' caption='[[2iyo]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='2iyo' size='340' side='right'caption='[[2iyo]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2iyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_lactis"_lister_1873 "bacterium lactis" lister 1873]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IYO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2iyo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IYO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6PG:6-PHOSPHOGLUCONIC+ACID'>6PG</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2iyp|2iyp]], [[2iz0|2iz0]], [[2iz1|2iz1]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6PG:6-PHOSPHOGLUCONIC+ACID'>6PG</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyo OCA], [https://pdbe.org/2iyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iyo RCSB], [https://www.ebi.ac.uk/pdbsum/2iyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyo OCA], [http://pdbe.org/2iyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iyo RCSB], [http://www.ebi.ac.uk/pdbsum/2iyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyo ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/6PGD_LACLM 6PGD_LACLM]] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity).
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[https://www.uniprot.org/uniprot/6PGD_LACLM 6PGD_LACLM] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[6-phosphogluconate dehydrogenase|6-phosphogluconate dehydrogenase]]
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*[[6-phosphogluconate dehydrogenase 3D structures|6-phosphogluconate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacterium lactis lister 1873]]
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[[Category: Lactococcus lactis]]
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[[Category: Hunter, W N]]
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[[Category: Large Structures]]
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[[Category: Iulek, J]]
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[[Category: Hunter WN]]
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[[Category: Sundaramoorthy, R]]
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[[Category: Iulek J]]
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[[Category: 6-phosphogluconate dehydrogenase]]
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[[Category: Sundaramoorthy R]]
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[[Category: Gluconate utilization]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase]]
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[[Category: Pentose shunt]]
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Structural characterization of a bacterial 6PDH reveals aspects of specificity, mechanism and mode of inhibition

PDB ID 2iyo

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