3hkv

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==Human poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide==
==Human poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide==
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<StructureSection load='3hkv' size='340' side='right' caption='[[3hkv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3hkv' size='340' side='right'caption='[[3hkv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HKV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hkv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HKV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PARP10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hkv OCA], [https://pdbe.org/3hkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hkv RCSB], [https://www.ebi.ac.uk/pdbsum/3hkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hkv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hkv OCA], [http://pdbe.org/3hkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hkv RCSB], [http://www.ebi.ac.uk/pdbsum/3hkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hkv ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAR10_HUMAN PAR10_HUMAN]] May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.<ref>PMID:15674325</ref> <ref>PMID:16455663</ref>
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[https://www.uniprot.org/uniprot/PAR10_HUMAN PAR10_HUMAN] May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.<ref>PMID:15674325</ref> <ref>PMID:16455663</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Berg, S Van Den]]
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[[Category: Arrowsmith CH]]
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[[Category: Berglund, H]]
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[[Category: Berglund H]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Collins, R]]
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[[Category: Collins R]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Flodin, S]]
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[[Category: Flodin S]]
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[[Category: Flores, A]]
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[[Category: Flores A]]
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[[Category: Graslund, S]]
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[[Category: Graslund S]]
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[[Category: Hammarstrom, M]]
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[[Category: Hammarstrom M]]
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[[Category: Johansson, A]]
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[[Category: Johansson A]]
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[[Category: Johansson, I]]
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[[Category: Johansson I]]
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[[Category: Karlberg, T]]
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[[Category: Karlberg T]]
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[[Category: Kotenyova, T]]
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[[Category: Kotenyova T]]
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[[Category: Kotzsch, A]]
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[[Category: Kotzsch A]]
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[[Category: Moche, M]]
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[[Category: Moche M]]
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[[Category: Nielsen, T K]]
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[[Category: Nielsen TK]]
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[[Category: Nordlund, P]]
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[[Category: Nordlund P]]
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[[Category: Nyman, T]]
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[[Category: Nyman T]]
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[[Category: Persson, C]]
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[[Category: Persson C]]
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[[Category: Roos, A K]]
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[[Category: Roos AK]]
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[[Category: Structural genomic]]
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[[Category: Sagemark J]]
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[[Category: Sagemark, J]]
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[[Category: Schuler H]]
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[[Category: Schuler, H]]
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[[Category: Schutz P]]
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[[Category: Schutz, P]]
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[[Category: Siponen MI]]
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[[Category: Siponen, M I]]
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[[Category: Thorsell AG]]
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[[Category: Thorsell, A G]]
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[[Category: Tresaugues L]]
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[[Category: Tresaugues, L]]
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[[Category: Van Den Berg S]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Welin, M]]
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[[Category: Welin M]]
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[[Category: Wisniewska, M]]
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[[Category: Wisniewska M]]
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[[Category: Cytoplasm]]
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[[Category: Glycosyltransferase]]
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[[Category: Nad]]
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[[Category: Nucleus]]
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[[Category: Parp]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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Current revision

Human poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide

PDB ID 3hkv

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