6fwc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:58, 17 October 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of human monoamine oxidase B (MAO B) in complex with fluorophenyl-chromone-carboxamide==
==Crystal structure of human monoamine oxidase B (MAO B) in complex with fluorophenyl-chromone-carboxamide==
-
<StructureSection load='6fwc' size='340' side='right' caption='[[6fwc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+
<StructureSection load='6fwc' size='340' side='right'caption='[[6fwc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6fwc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FWC FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6fwc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FWC FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene>, <scene name='pdbligand=E98:~{N}-(3-fluorophenyl)-4-oxidanylidene-chromene-3-carboxamide'>E98</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAOB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene>, <scene name='pdbligand=E98:~{N}-(3-fluorophenyl)-4-oxidanylidene-chromene-3-carboxamide'>E98</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fwc OCA], [https://pdbe.org/6fwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fwc RCSB], [https://www.ebi.ac.uk/pdbsum/6fwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fwc ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fwc OCA], [http://pdbe.org/6fwc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fwc RCSB], [http://www.ebi.ac.uk/pdbsum/6fwc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fwc ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN]] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
+
[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 19:
</div>
</div>
<div class="pdbe-citations 6fwc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6fwc" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Monoamine oxidase|Monoamine oxidase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Monoamine oxidase]]
+
[[Category: Large Structures]]
-
[[Category: Binda, C]]
+
[[Category: Binda C]]
-
[[Category: Borges, F]]
+
[[Category: Borges F]]
-
[[Category: Cagide, F]]
+
[[Category: Cagide F]]
-
[[Category: Manzella, N]]
+
[[Category: Manzella N]]
-
[[Category: Mialet-Perez, J]]
+
[[Category: Mialet-Perez J]]
-
[[Category: Parini, A]]
+
[[Category: Parini A]]
-
[[Category: Reis, J]]
+
[[Category: Reis J]]
-
[[Category: Uriarte, E]]
+
[[Category: Uriarte E]]
-
[[Category: Chromone]]
+
-
[[Category: Drug design]]
+
-
[[Category: Flavoprotein]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Parkinson's disease]]
+

Current revision

Crystal structure of human monoamine oxidase B (MAO B) in complex with fluorophenyl-chromone-carboxamide

PDB ID 6fwc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6fwc"
Personal tools