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2cr8
From Proteopedia
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==Solution structure of the zf-RanBP domain of p53-binding protein Mdm4== | ==Solution structure of the zf-RanBP domain of p53-binding protein Mdm4== | ||
| - | <StructureSection load='2cr8' size='340' side='right' caption='[[2cr8 | + | <StructureSection load='2cr8' size='340' side='right'caption='[[2cr8]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cr8]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2cr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CR8 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [https://pdbe.org/2cr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[MDM2|MDM2]] | ||
*[[MDM4|MDM4]] | *[[MDM4|MDM4]] | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Hayashi F]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
| - | [[Category: Zhang | + | [[Category: Zhang HP]] |
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Current revision
Solution structure of the zf-RanBP domain of p53-binding protein Mdm4
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