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2ch1

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==Structure of Anopheles gambiae 3-hydroxykynurenine transaminase==
==Structure of Anopheles gambiae 3-hydroxykynurenine transaminase==
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<StructureSection load='2ch1' size='340' side='right' caption='[[2ch1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='2ch1' size='340' side='right'caption='[[2ch1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ch1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Anoga Anoga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CH1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ch1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CH1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ch2|2ch2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ch1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch1 OCA], [http://pdbe.org/2ch1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ch1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ch1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ch1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch1 OCA], [https://pdbe.org/2ch1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ch1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ch1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch1 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HKT_ANOGA HKT_ANOGA] Catalyzes the pyridoxal 5'-phosphate-dependent transamination of both 3-hydroxykynurenine and L-kynurenine to xanthurenic acid and kynurenic acid, respectively, preferentially using the alpha-ketoacid glyoxylate as the amino group acceptor (PubMed:16262702). Although glyoxylate is the preferred amino group acceptor, transamination of 3-hydroxykynurenine also works with pyruvate as the amino acceptor in vitro (PubMed:16262702). Involved in the detoxification of cytotoxic metabolite 3-hydroxykynurenine generated by the hydroxylation of L-kynurenine, an intermediate in the tryptophan catabolism pathway (PubMed:16262702). The Plasmodium parasite uses xanthurenic acid produced in the midgut to activate its gametocytes ingested during a blood meal (Probable). Also catalyzes, although with a lesser efficiency, the transamination of alanine with glyoxylate as an amino group acceptor (By similarity). May play a role in the detoxification of glyoxylate, a toxic plant metabolite from the diet (By similarity).[UniProtKB:Q0IG34]<ref>PMID:16262702</ref> <ref>PMID:16262702</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Anoga]]
 
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[[Category: Arca, B]]
 
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[[Category: Garavaglia, S]]
 
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[[Category: Giovenzana, G B]]
 
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[[Category: Li, J]]
 
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[[Category: Rizzi, M]]
 
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[[Category: Rossi, F]]
 
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[[Category: 3-hydroxykynurenine transaminase]]
 
[[Category: Anopheles gambiae]]
[[Category: Anopheles gambiae]]
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[[Category: Kynurenine pathway]]
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[[Category: Large Structures]]
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[[Category: Plp-enzyme]]
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[[Category: Arca B]]
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[[Category: Transferase]]
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[[Category: Garavaglia S]]
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[[Category: Giovenzana GB]]
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[[Category: Li J]]
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[[Category: Rizzi M]]
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[[Category: Rossi F]]

Current revision

Structure of Anopheles gambiae 3-hydroxykynurenine transaminase

PDB ID 2ch1

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